| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| Other Sizes |
| Targets |
IC50: 34 nM (ELOVL6)[1]
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|---|---|
| ln Vivo |
ELOVL6-IN-2 (0.1~1mg/kg; oral) effectively and dose-proportionally inhibits the elongation index in the liver[1]. ELOVL6-IN-2 (10mg/kg; oral) exhibits high liver permeability[1]. ELOVL6-IN-2 (1mg/kg; oral 2~24 hours) exhibits sustained plasma exposure[1].
|
| Animal Protocol |
Animal/Disease Models: Male C57BL/6J mice
Doses: 0.1~1mg/kg Route of Administration: P.o Experimental Results: Potently and dose-proportionally suppressed the elongation index in the liver. Animal/Disease Models: Male C57BL/6J mice Doses: 10 mg/kg Route of Administration: P.o Experimental Results: Demonstrated highly liver penetrable. Animal/Disease Models: Male C57BL/6J mice Doses: 1 mg/kg Route of Administration: P.o Experimental Results: Exhibited sustained plasma exposure. |
| References |
| Molecular Formula |
C28H23F6N3O4
|
|---|---|
| Molecular Weight |
579.49
|
| CAS # |
1067647-43-1
|
| PubChem CID |
44139567
|
| Appearance |
White to off-white solid powder
|
| LogP |
5.928
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
41
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| Complexity |
1190
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=C(C(=O)N(C2=CC=C(C=C2)OC(F)(F)F)N1)C3(C4=C(CC(C)(C)CC4=O)N(C5=CC=CC=C5)C3=O)C(F)(F)F
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~172.57 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (4.31 mM) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one),suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300, mix well; then add 50 μL Tween-80 to the above system, mix well; then continue to add 450 μL of normal saline to make up to 1 mL. Preparation of normal saline: Dissolve 0.9 g of sodium chloride in ddH₂O and make up to 100 mL to obtain a clear and transparent normal saline solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.31 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7257 mL | 8.6283 mL | 17.2566 mL | |
| 5 mM | 0.3451 mL | 1.7257 mL | 3.4513 mL | |
| 10 mM | 0.1726 mL | 0.8628 mL | 1.7257 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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