| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Proctolin stimulates resting systems and raises action potential frequency and amplitude [1]. It also enhances muscular contraction amplitude. Proctolin functions as a neuromodulator and maybe a neurohormone in arthropods. It doesn't seem to perform like a conventional neurotransmitter [2]. The first insect neuropeptide to be chemically and sequence-characterized is proctolin, a pentapeptide containing the mature peptide RYLPT. CG7105 in Drosophila melanogaster was the first proctolin precursor gene to be identified. Even so, prior research indicated that B lacks proctolin. Mori, a proteomic investigation of B recently revealed the presence of this pentapeptide. mori wings. A similar gene was found in the Borer borer, but the Bombyx mori Proctolin gene does not provide mature peptides due to the absence of cleavage sites at the N- and C-termini of the RYLPT sequence. As a result, it is thought that neither Bombyx mori nor Borer borer have shown signs of having real Proctolin[3].
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| References | |
| Additional Infomation |
Proctolin is a peptide.
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| Exact Mass |
648.36
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|---|---|
| CAS # |
57966-42-4
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| PubChem CID |
123786
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| Appearance |
White to off-white solid powder
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| LogP |
2.832
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| Hydrogen Bond Donor Count |
9
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
17
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| Heavy Atom Count |
46
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| Complexity |
1080
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| Defined Atom Stereocenter Count |
6
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| SMILES |
N/C(=N/CCCC(C(NC(C(NC(C(N1CCCC1C(NC(C(=O)O)C(O)C)=O)=O)CC(C)C)=O)CC1=CC=C(O)C=C1)=O)N)/N
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| InChi Key |
KKUPPLMEDQDAJX-UEHMALFGSA-N
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| InChi Code |
InChI=1S/C30H48N8O8/c1-16(2)14-22(28(44)38-13-5-7-23(38)27(43)37-24(17(3)39)29(45)46)36-26(42)21(15-18-8-10-19(40)11-9-18)35-25(41)20(31)6-4-12-34-30(32)33/h8-11,16-17,20-24,39-40H,4-7,12-15,31H2,1-3H3,(H,35,41)(H,36,42)(H,37,43)(H,45,46)(H4,32,33,34)/t17-,20+,21+,22+,23+,24+/m1/s1
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| Chemical Name |
(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
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| Synonyms |
Gut factor Proctolin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~154.14 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 100 mg/mL (154.14 mM) (saturation unknown) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution.
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT03366090 | UNKNOWN STATUS | Procedure: Biopsies during coloscopy | Crohn Disease IBD Immunological Profiles Immunology |
Rijnstate Hospital | 2017-10-01 | |
| NCT06495658 | RECRUITING | Dietary Supplement: Prebiotic | Crohn Disease Ulcerative Colitis |
University of California, Los Angeles | 2024-07-09 | Not Applicable |
| NCT00445627 | COMPLETED | Drug: Metformin Drug: Insulin Behavioral: Nutrition counseling Behavioral: Exercise counseling |
Diabetes Mellitus, Type 2 Obesity Overweight |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2007-06-18 |
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