| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Pro-Xylane targets the biosynthesis of glycosaminoglycans (GAGs) in the skin. It effectively promotes the synthesis of collagen fibers and hyaluronic acid in the dermis. By activating GAG biosynthesis, it improves skin hydration and elasticity. Its mechanism of action is related to its role as a biosynthetic activator of extracellular matrix components.
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| ln Vitro |
Pro-Xylane is a biosynthetic activator of glycosaminoglycans (GAGs). It promotes the synthesis of collagen fibers and hyaluronic acid in the dermis. Its activity has been confirmed in various in vitro skin models. It is the first example of a 'Green' chemical used in cosmetics.
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| ln Vivo |
Pro-Xylane improves skin hydration and elasticity in vivo. It has anti-aging, moisturizing, and skin-firming effects. It is used in cosmetic products to enhance the skin's protective barrier. It is eco-friendly and biodegradable.
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| Enzyme Assay |
Pro-Xylane does not have a typical enzyme/receptor binding assay. Its activity is assessed based on its ability to stimulate GAG synthesis in skin cell cultures. Skin fibroblasts or other relevant cell types are treated with the compound, and the production of GAGs, collagen, and hyaluronic acid is measured using biochemical assays or histochemical staining.
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| Cell Assay |
In vitro cellular experiments for Pro-Xylane involve treating skin fibroblasts or keratinocytes with the compound and measuring its effects on GAG synthesis, collagen production, and cell proliferation. The synthesis of hyaluronic acid and other GAGs is measured using ELISA or other biochemical methods. Collagen synthesis is assessed by measuring collagen production or by using specific stains.
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| Animal Protocol |
In vivo animal experiments for Pro-Xylane would involve topical application of the compound to animal skin to assess its effects on skin hydration, elasticity, and thickness. Its effects on GAG and collagen synthesis in the skin would be assessed by histological analysis and biochemical assays.
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| ADME/Pharmacokinetics |
Pro-Xylane has a molecular weight of 192.21 g/mol and a molecular formula of C8H16O5. The IUPAC name is (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol. It is a solid at room temperature. It is soluble in water and organic solvents. It is typically stored at room temperature. Its purity is typically ≥99%.
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| Toxicity/Toxicokinetics |
Pro-Xylane is generally recognized as safe for use in cosmetic products. It is considered to have low toxicity and is well-tolerated by the skin. It is eco-friendly and biodegradable. It is not intended for human ingestion or therapeutic use.
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| References | |
| Additional Infomation |
Hydroxypropyl tetrahydropyranotriol has been used in experiments to study the basic science of aging.
Pro-Xylane (hydroxypropyl tetrahydropyrantriol) is a cosmetic ingredient derived from xylose that acts as a biosynthetic activator of glycosaminoglycans. It promotes the synthesis of collagen and hyaluronic acid in the skin and is used as an anti-aging agent. The compound is available from various chemical suppliers for research and cosmetic development purposes. |
| Molecular Formula |
C8H16O5
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|---|---|
| Molecular Weight |
192.21
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| Exact Mass |
192.1
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| CAS # |
439685-79-7
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| Related CAS # |
(S)-Pro-xylane;868156-46-1
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| PubChem CID |
16666733
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.368±0.06 g/cm3
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| Boiling Point |
376.0±42.0 °C
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| LogP |
-1.8
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
13
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| Complexity |
163
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O1C[C@H]([C@@H]([C@H]([C@@H]1CC(C)O)O)O)O
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| InChi Key |
KOGFZZYPPGQZFZ-QVAPDBTGSA-N
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| InChi Code |
InChI=1S/C8H16O5/c1-4(9)2-6-8(12)7(11)5(10)3-13-6/h4-12H,2-3H2,1H3/t4?,5-,6+,7+,8+/m1/s1
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| Chemical Name |
(2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol
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| Synonyms |
Mexoryl SBB; Pro-xylane; Hydroxypropyl tetrahydropyrantriol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~1300.66 mM)
DMSO : ≥ 83.33 mg/mL (~433.54 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.82 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.82 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.82 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (520.26 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL | |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL | |
| 10 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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