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| 5mg |
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PQCA is a muscarinic M1 receptor positive allosteric modulator. PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. PQCA displays robust efficacy in rodent and nonhuman primate (NHP) cognition assays. PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model. PQCA may be potential useful in finding new drugs for patients with Alzheimer's diseases
| ln Vivo |
PQCA (3-30 mg/kg; oral; male rhesus monkeys housed singly or in pairs) therapy decreased scopolamine deficits on PAL and CPT tests. Blockade of muscarinic signaling by scopolamine severely worsens both tasks [1].
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| Animal Protocol |
Animal/Disease Models: Ten single or paired male rhesus monkeys (6-10 years old; 5.2-10.5 kg) were administered scopolamine [1]
Doses: 3 mg/kg, 10 mg/kg or 30 mg/kg Route of Administration: Oral Experimental Results: Attenuated scopolamine deficits in paired associate learning (PAL) and continuous performance tasks (CPT). |
| References |
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| Molecular Formula |
C22H20N4O3
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|---|---|
| Molecular Weight |
388.427
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| Exact Mass |
388.154
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| CAS # |
1144504-35-7
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| Related CAS # |
1401512-98-8 (sodium);1144504-35-7 (free acid);
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| PubChem CID |
25229646
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| Appearance |
White to yellow solid powder
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| LogP |
2.387
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
29
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| Complexity |
881
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
RJTJRVASUFIDQM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H20N4O3/c23-15-22(19-6-1-3-9-24-19)7-11-25(12-8-22)14-16-13-17(21(28)29)20(27)26-10-4-2-5-18(16)26/h1-6,9-10,13H,7-8,11-12,14H2,(H,28,29)
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| Chemical Name |
1-[(4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl]-4-oxoquinolizine-3-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~25.75 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (2.57 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5745 mL | 12.8723 mL | 25.7447 mL | |
| 5 mM | 0.5149 mL | 2.5745 mL | 5.1489 mL | |
| 10 mM | 0.2574 mL | 1.2872 mL | 2.5745 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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