| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
The MIC values of povidone-iodine (PVP-I) are 31.25 mg/L and 7.82 mg/L respectively. Treatment of cells with povidone-iodine (PVP-I) at a 1:32 dilution resulted in a substantial 90-95% drop in cell viability in all cell lines examined [1].
|
|---|---|
| ln Vivo |
The group that received Dp + povidone-iodine (PVP-I) had the second-highest mean score from day 13 until the conclusion of the study period. Additionally, compared to the control group, the Dp+povidone-iodine and Dp+Et-OH groups had significantly higher eosinophil counts (p<0.05 and p<0.001, respectively). The eosinophil counts of the Dp+povidone-iodine (PVP-I), Dp+CHG, and Dp+vehicle groups did not, however, differ significantly [2].
|
| References |
|
| Additional Infomation |
An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.
See also: Povidone-Iodine (annotation moved to). |
| Molecular Formula |
C6H9I2NO
|
|---|---|
| Molecular Weight |
364.9507
|
| Exact Mass |
364.877
|
| CAS # |
25655-41-8
|
| PubChem CID |
410087
|
| Appearance |
Typically exists as solid at room temperature
|
| Boiling Point |
217.6ºC at 760 mmHg
|
| Melting Point |
300ºC
|
| Flash Point |
93.9ºC
|
| Vapour Pressure |
0.132mmHg at 25°C
|
| LogP |
2.461
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
10
|
| Complexity |
120
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
II.O=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])=C([H])[H]
|
| InChi Key |
CPKVUHPKYQGHMW-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;
|
| Chemical Name |
1-ethenylpyrrolidin-2-one;molecular iodine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~15 mg/mL
H2O : ~2.4 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 15.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 15.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 100 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7401 mL | 13.7005 mL | 27.4010 mL | |
| 5 mM | 0.5480 mL | 2.7401 mL | 5.4802 mL | |
| 10 mM | 0.2740 mL | 1.3701 mL | 2.7401 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Topical Insulin for Postoperative Wound Healing
CTID: NCT06400082
Phase: N/A Status: Active, not recruiting
Date: 2024-08-21
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
