| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
By altering granules' surface characteristics, Tween 20 can reduce ineffective protein adsorption by altering surface adsorption, hydrogen bonding ability, and adsorption [1]. The apparent solubility of the medication can be greatly increased from 0.8 μg/mL to 353 μg/mL when Tween 20 (0.35%-0.7% w/w) is added to 0.05 mol/L pH 6.5 phosphate buffer. However, its effect is less pronounced at lower pH values or in water (20 μg/mL at pH 4.5). The solubility of candesartan medoxomil increased to 620 μg/mL when the phosphate concentration (0.2 M) was increased at pH 6.5 in the presence of 0.7% polysorbate 20 [2].
|
|---|---|
| References |
|
| Additional Infomation |
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethylenedimethyl) derivative; a complex mixture of polyoxyethylene ethers used as pharmaceutical emulsifiers or dispersants. See also: PEG-80 sorbitan laurate (note moved to); polysorbate 20 (note moved to).
|
| Molecular Formula |
C26H50O10
|
|---|---|
| Molecular Weight |
522.6692
|
| Exact Mass |
604.418
|
| CAS # |
9005-64-5
|
| Related CAS # |
9005-66-7;9005-64-5
|
| PubChem CID |
443314
|
| Appearance |
Colorless to light yellow viscous liquid
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
695.8±55.0 °C at 760 mmHg
|
| Flash Point |
207.1±25.0 °C
|
| Vapour Pressure |
0.0±5.0 mmHg at 25°C
|
| Index of Refraction |
1.502
|
| LogP |
5.37
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
10
|
| Rotatable Bond Count |
26
|
| Heavy Atom Count |
36
|
| Complexity |
507
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O1C([H])([H])C([H])(C([H])(C1([H])C([H])(C([H])([H])OC([H])([H])C([H])([H])OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)OC([H])([H])C([H])([H])O[H])OC([H])([H])C([H])([H])O[H])OC([H])([H])C([H])([H])O[H]
|
| InChi Key |
HMFKFHLTUCJZJO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
|
| Chemical Name |
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9133 mL | 9.5663 mL | 19.1325 mL | |
| 5 mM | 0.3827 mL | 1.9133 mL | 3.8265 mL | |
| 10 mM | 0.1913 mL | 0.9566 mL | 1.9133 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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