| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
|
||
| Other Sizes |
| Targets |
Poly(hexamethylenebiguanide) HCl targets bacterial and viral membranes. It binds to and disrupts cytoplasmic membranes. It is a cationic polymer that interacts with negatively charged microbial membranes, causing membrane disruption and cell death. It is a broad-spectrum antimicrobial agent.
|
|---|---|
| ln Vitro |
In vitro, Poly(hexamethylenebiguanide) HCl is a broad-spectrum antimicrobial agent. It is active against both Gram-positive and Gram-negative bacteria. It is used as a disinfectant. It binds and disrupts cytoplasmic membranes.
|
| ln Vivo |
In vivo, Poly(hexamethylenebiguanide) HCl is used as an antimicrobial agent in medical, clothing, and home textile fields. It is low toxic. However, specific in vivo efficacy data in animal models are not detailed in the available literature.
|
| Enzyme Assay |
There are no in vitro enzyme/receptor binding assays for Poly(hexamethylenebiguanide) HCl as it is an antimicrobial polymer, not an enzyme inhibitor. Its activity is assessed by its ability to kill bacteria and viruses.
|
| Cell Assay |
In vitro cell-based assays for Poly(hexamethylenebiguanide) HCl involve treating bacterial or viral cultures with the compound and assessing growth inhibition or viral replication. The compound's antimicrobial activity is evaluated by determining minimum inhibitory concentrations (MIC).
|
| Animal Protocol |
In vivo animal studies for Poly(hexamethylenebiguanide) HCl would likely involve infection models in rodents. The compound would be administered topically or systemically, and microbial load in tissues would be measured. However, specific protocols are not detailed in the available literature.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of Poly(hexamethylenebiguanide) HCl are not characterized as it is not a drug. It is a water-soluble polymer.
|
| Toxicity/Toxicokinetics |
No specific toxicity data for Poly(hexamethylenebiguanide) HCl are available in the provided literature. It is low toxic. The compound is for research use only.
|
| Additional Infomation |
Poly(hexamethylenebiguanide) HCl is a broad-spectrum antimicrobial polymer. It is active against Gram-positive and Gram-negative bacteria. It is used as a disinfectant. Its CAS number is 32289-58-0.
|
| Molecular Formula |
(C8H17N5)N.XHCL
|
|---|---|
| Molecular Weight |
433.03814
|
| Exact Mass |
213.195
|
| CAS # |
32289-58-0
|
| Related CAS # |
32289-58-0
|
| PubChem CID |
57345804
|
| Appearance |
Typically exists as solid at room temperature
|
| LogP |
-0.4
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
15
|
| Complexity |
210
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
SAGIGHPRUJPLKX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15)
|
| Chemical Name |
N'-[6-[(N'-methylcarbamimidoyl)amino]hexyl]ethanimidamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3093 mL | 11.5463 mL | 23.0926 mL | |
| 5 mM | 0.4619 mL | 2.3093 mL | 4.6185 mL | |
| 10 mM | 0.2309 mL | 1.1546 mL | 2.3093 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
