| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| Other Sizes |
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| ln Vitro |
Podocarpic anhydride agonistically interacts with LXRα and β receptors at 1 nM.It is more than 8–10 times more efficient than one of the natural ligands, 22–(R)–hydroxycholesterol, as an LXR receptor activator in HEK-293 cells [2].
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|---|---|
| ln Vivo |
SKN-1 in C is activated by mogrosanic acid. elegans, making it comparable to well-known Nrf2 activators like LA. Additionally, SKN-1 activation produced by mohenate or LA requires TRPodocarpic Acid-1; in glod-4;gst-4p::gfp mice, trPodocarpic Acid-1 knockdown restored gst-4 expression to wild-type levels. The strong Ca2+ flux that was induced by supplementing with A and LA was greatly diminished when the Ca2+-impermeable TRPodocarpic Acid-1E1018A channel was present, suggesting that TRPodocarpic Acid-1 activation is essential for the therapeutic effects of these agents. Ultimately, high endogenous MGO and GO were restored to levels almost identical to wild type by podocarpus acid and LA, which mitigated the podocarbin acidogenic phenotype of glod-4 animals [1].
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| References |
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| Additional Infomation |
Podocarpic acid is an abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position. It derives from a hydride of a podocarpane.
Podocarpic acid has been reported in Podocarpus totara, Dacrycarpus dacrydioides, and other organisms with data available. |
| Molecular Formula |
C17H22O3
|
|---|---|
| Molecular Weight |
274.35478
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| Exact Mass |
274.157
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| CAS # |
5947-49-9
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| PubChem CID |
93017
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| Appearance |
White to off-white solid powder
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| Melting Point |
193-196 ℃(lit.)
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| LogP |
3.487
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
20
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| Complexity |
407
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| Defined Atom Stereocenter Count |
3
|
| SMILES |
C[C@]12CCC[C@]([C@@H]1CCC3=C2C=C(C=C3)O)(C)C(=O)O
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| InChi Key |
VJILEYKNALCDDV-OIISXLGYSA-N
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| InChi Code |
InChI=1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1
|
| Chemical Name |
(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~364.50 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6450 mL | 18.2249 mL | 36.4498 mL | |
| 5 mM | 0.7290 mL | 3.6450 mL | 7.2900 mL | |
| 10 mM | 0.3645 mL | 1.8225 mL | 3.6450 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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