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PKM2 activator 2, pyruvate kinase M2 (PKM2) activitor with anti-tumor activity. It activates PKM2 with an AC50 value of 66 nM.
| ln Vitro |
PKM2 causes an increase in the availability of glycolytic intermediates, which are necessary for the production of lipids, amino acids, and nucleic acids—the building blocks of cells—in cancer cells. On the other hand, tumors and cancer cell lines show downregulated expression of PKM2 and its dimeric form [1]. In a luciferase-coupled test, PKM2 Activator 2 (Compound 28) has an AC50 value of 66 nM, making it a highly potent activator of pyruvate kinase [1].
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| References | |
| Additional Infomation |
1-(2,6-difluorophenyl)sulfonyl-4-(2-naphthalenylsulfonyl)piperazine is a sulfonic acid derivative and a member of naphthalenes.
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| Molecular Formula |
C20H18F2N2O4S2
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|---|---|
| Molecular Weight |
452.49472951889
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| Exact Mass |
452.067
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| CAS # |
1186660-06-9
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| PubChem CID |
25243723
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| Appearance |
White to off-white solid powder
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| LogP |
3.1
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
30
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| Complexity |
794
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N1(S(C2=C(F)C=CC=C2F)(=O)=O)CCN(S(C2=CC=C3C(=C2)C=CC=C3)(=O)=O)CC1
|
| InChi Key |
LLOHMBFPOYWAIL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H18F2N2O4S2/c21-18-6-3-7-19(22)20(18)30(27,28)24-12-10-23(11-13-24)29(25,26)17-9-8-15-4-1-2-5-16(15)14-17/h1-9,14H,10-13H2
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| Chemical Name |
1-(2,6-difluorophenyl)sulfonyl-4-naphthalen-2-ylsulfonylpiperazine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~5 mg/mL (~11.05 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2100 mL | 11.0500 mL | 22.0999 mL | |
| 5 mM | 0.4420 mL | 2.2100 mL | 4.4200 mL | |
| 10 mM | 0.2210 mL | 1.1050 mL | 2.2100 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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