| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| 500mg | |||
| Other Sizes |
| Toxicity/Toxicokinetics |
Effects During Pregnancy and Lactation
◉ Overview of Use During Lactation Ampicillin (pimidocilin; pitavali ester of mecillin) is not marketed in the United States but is sold internationally. Limited information suggests that concentrations of ampicillin in breast milk are low and are not expected to have adverse effects on breastfed infants. Breastfed infants should be monitored for diarrhea and thrush. ◉ Effects on Breastfed Infants No published information found as of the revision date. ◉ Effects on Lactation and Breast Milk No published information found as of the revision date. |
|---|---|
| References |
|
| Additional Infomation |
Ampicillin valerate methyl ester is well absorbed orally but breaks down into ampicillin in the intestinal mucosa. It is effective against Gram-negative bacteria and has the same uses as ampicillin.
See also: Ampicillin ester (note moved to). |
| Molecular Formula |
C21H34CLN3O5S
|
|---|---|
| Molecular Weight |
476.03
|
| Exact Mass |
475.19
|
| CAS # |
32887-03-9
|
| Related CAS # |
Pivmecillinam;32886-97-8
|
| PubChem CID |
115162
|
| Appearance |
White to off-white solid powder
|
| Density |
1.3g/cm3
|
| Boiling Point |
581ºC at 760mmHg
|
| Melting Point |
172-173°
|
| Flash Point |
305.2ºC
|
| LogP |
3.089
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
31
|
| Complexity |
710
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N=CN3CCCCCC3)C(=O)OCOC(=O)C(C)(C)C)C.Cl
|
| InChi Key |
UHPXMYLONAGUPC-WKLLBTDKSA-N
|
| InChi Code |
InChI=1S/C21H33N3O5S.ClH/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23;/h12,14-15,17H,6-11,13H2,1-5H3;1H/t14-,15+,17-;/m1./s1
|
| Chemical Name |
2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride
|
| Synonyms |
Pivmecillinam (hydrochloride); Melysin; Pivmecillinam Hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~210.07 mM)
DMSO : ≥ 34 mg/mL (~71.42 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 12.5 mg/mL (26.26 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1007 mL | 10.5035 mL | 21.0071 mL | |
| 5 mM | 0.4201 mL | 2.1007 mL | 4.2014 mL | |
| 10 mM | 0.2101 mL | 1.0504 mL | 2.1007 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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