| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
The ethanolamine salt of the hydroxypyridone antifungal drug Piroctone, which is derived from hydroxamic acid, is called piroctone olamine. Piroctone ethanolamine has the ability to cross cell membranes, bind to iron ions to create a complex, and obstruct the metabolism of mitochondrial energy [1]. The ethanolamine salt of the hydroxamic acid derivative piroctone is called piroctone olamine (PO). The minimum inhibitory concentrations (MIC) of amphotericin B (AMB) (0.03-1 μg/mL) and piroctone ethanolamine (0.125-0.5 μg/mL) were low in all Candida strains [2].
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| ln Vivo |
The aim of this study was to assess the antifungal efficacy of piroctone ethanolamine in treating intra-abdominal candidiasis in a Swiss mouse model. 72 hours after infection, intraperitoneal injection of piroctone ethanolamine (0.5 mg/kg) was used as a treatment. Amphotericin B (0.5 mg/kg) was administered to a group of six animals as a comparative study. The kidneys, spleen, and liver were removed in order to make a mycological diagnosis. The significance level was chosen at P<0.05 for the statistical analysis of the fungal growth and mortality data using the Student's t test and analysis of variance. There was a statistically significant (P<0.05) difference in the fungal growth ratings between the amphotericin B and pyroacetic acid treatment group and the control group [2].
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| References |
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| Additional Infomation |
See also: Piroctone (has active moiety).
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| Molecular Formula |
C16H30N2O3MOLECULARWEIGHT
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| Molecular Weight |
298.4210
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| Exact Mass |
298.225
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| CAS # |
68890-66-4
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| Related CAS # |
50650-76-5;68890-66-4 (olamine);
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| PubChem CID |
50258
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| Appearance |
White to off-white solid powder
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| Density |
1.1 g/cm3 at 21.5 °C
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| Boiling Point |
344.1ºC at 760 mmHg
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| Melting Point |
130 - 135ºC
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| Flash Point |
161.9ºC
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| LogP |
2.646
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
21
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| Complexity |
371
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BTSZTGGZJQFALU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
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| Chemical Name |
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~50 mg/mL (~167.55 mM)
DMSO : ~11.11 mg/mL (~37.23 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.11 mg/mL (3.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 11.1 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.11 mg/mL (3.72 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 11.1 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.11 mg/mL (3.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3510 mL | 16.7549 mL | 33.5098 mL | |
| 5 mM | 0.6702 mL | 3.3510 mL | 6.7020 mL | |
| 10 mM | 0.3351 mL | 1.6755 mL | 3.3510 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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