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    Piracetam (UCB-6215)
    Piracetam (UCB-6215)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1094
    CAS #: 7491-74-9Purity ≥98%

    Description: Piracetam (BRN-1526393; UCB-6215; Cl-871; Breinox; Ciclofalina; Euvifor; Gabacet; Nootron) is a cyclized derivative of the neurotransmitter gamma-aminobutyric acid (GABA) that has been approved for use in the treatment of a wide range of cognitive disorders. Piracetam is considered to be both a nootropic and a neuroprotective agent. Piracetam is a positive allosteric modulator of the AMPA receptor. It is believed to act on ion channels or ion carriers, thus leading to increased neuron excitability. 

    References: Biochim Biophys Acta. 2003 Jan 10;1609(1):28-38; Biochem Pharmacol. 1997 Jan 24;53(2):135-40.

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    Molecular Weight (MW)142.16
    FormulaC6H10N2O2
    CAS No.7491-74-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 72 mg/mL (506.5 mM)
    Water: 72 mg/mL (506.5 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 1-Acetamido-2-pyrrolidinone

    InChi Key: SIXPSGNZQPKXTG-UHFFFAOYSA-N

    InChi Code: InChI=1S/C6H10N2O2/c1-5(9)7-8-4-2-3-6(8)10/h2-4H2,1H3,(H,7,9)

    SMILES Code: O=C1N(NC(C)=O)CCC1

    SynonymsUCB-6215; Piracetam; Breinox; BRN-1526393; UCB6215; UCB 6215; BRN1526393; Ciclofalina; Cl871; BRN 1526393; Cl-871; Cl 871; EINECS 231-312-7; Euvifor; Gabacet; Genogris; Nootron; Nootropil; Nootropyl; Normabrain.


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    In Vitro

    In vitro activity: Piracetam is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960). Piracetam (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH).

    In VivoPiracetam (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats. Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats. Piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor in aged mice. Piracetam-treated withdrawn rats has higher the number of synapses than that observed in nonpiracetam-treated and alcohol-fed animals by up to 20%, the mechanisms leading to the synaptic reorganization took place at the mossy fiber level.
    Animal modelMale Wistar rats 
    Formulation & DosageDissolved in saline; 300 mg/kg; oral gavage 
    References

    Biochem Pharmacol. 1997 Jan 24;53(2):135-40; Pharmacopsychiatry. 1999 Mar;32 Suppl 1:10-6; Pharmacology. 1993 Oct;47(4):217-22.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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