| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
Piperazine adipate (10 mM) causes death of chicken A. galli and H. gallinae after up to 30 minutes of exposure, decreases malate oxidation by 78%, and inhibits aldolase activity of both parasites. Piperazine adipate (10 mM) also suppresses cholinesterase activity in A. galli by 96% and H. gallinae by 93%. Piperazine adipate inhibits the degradation of oxaloacetate in A. galli and H. gallinae by 26% and 55% respectively [1].
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| References | |
| Additional Infomation |
Piperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257 °C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)
Piperazine adipate is a piperazinium salt obtained by combining equimolar amounts of piperazine and adipic acid. It has a role as an anthelminthic drug and an antinematodal drug. It contains an adipate(2-) and a piperazinium(2+). |
| Molecular Formula |
C10H20N2O4
|
|---|---|
| Molecular Weight |
232.2768
|
| Exact Mass |
232.142
|
| CAS # |
142-88-1
|
| Related CAS # |
110-85-0;142-88-1 (adipate);3546-41-6 (pamoate); 548-84-5 (Cl); 35648-29-4 (Iodide);
|
| PubChem CID |
8905
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
338.5ºC at 760 mmHg
|
| Melting Point |
250ºC (Decomposes)
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| Flash Point |
172.7ºC
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| Vapour Pressure |
1.81E-05mmHg at 25°C
|
| LogP |
0.552
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
16
|
| Complexity |
140
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BVEGEKOBSPXUJS-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H10O4.C4H10N2/c7-5(8)3-1-2-4-6(9)10;1-2-6-4-3-5-1/h1-4H2,(H,7,8)(H,9,10);5-6H,1-4H2
|
| Chemical Name |
hexanedioic acid;piperazine
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~14.29 mg/mL (~61.52 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (143.49 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3051 mL | 21.5257 mL | 43.0515 mL | |
| 5 mM | 0.8610 mL | 4.3051 mL | 8.6103 mL | |
| 10 mM | 0.4305 mL | 2.1526 mL | 4.3051 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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