| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 25mg |
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| Targets |
Pinocembrin 7-O-Beta-D-Glucoside targets lipid peroxidation pathways. As a flavonoid glycoside, it may modulate oxidative stress by enhancing lipid peroxidation, which can have implications for cell signaling and membrane dynamics. Its specific molecular targets are not well characterized, but its activity is consistent with flavonoid-mediated effects on cellular redox balance.
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| ln Vitro |
One flavonoid that was extracted from the dried entire plant of Viscum articulatum is called pinocembrin-7-O-β-D-glucopyranoside [2].
In vitro, Pinocembrin 7-O-Beta-D-Glucoside is a flavanone that enhances lipid peroxidation. This activity suggests it may modulate oxidative stress pathways and affect membrane lipid dynamics. As a flavonoid glycoside, it may also exhibit antioxidant or pro-oxidant properties depending on the cellular context. Its specific IC50 values and other potency data are not well established. |
| ln Vivo |
In vivo activity data for Pinocembrin 7-O-Beta-D-Glucoside are limited. Its in vitro enhancement of lipid peroxidation suggests potential systemic effects on oxidative stress and lipid metabolism. As a flavonoid glycoside, it may be hydrolyzed in the gastrointestinal tract to release the aglycone pinocembrin, which could exert additional biological activities. Further in vivo studies are needed to confirm its efficacy and safety.
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| Enzyme Assay |
In vitro assays for Pinocembrin 7-O-Beta-D-Glucoside are conducted to evaluate its effects on lipid peroxidation. Lipid peroxidation is typically measured using the thiobarbituric acid reactive substances (TBARS) assay or by monitoring the formation of malondialdehyde (MDA) in cell or tissue homogenates. The compound is incubated with lipid substrates, and the extent of peroxidation is quantified spectrophotometrically or fluorometrically.
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| Cell Assay |
Cellular assays for Pinocembrin 7-O-Beta-D-Glucoside are performed using various cell lines to study its effects on oxidative stress and lipid metabolism. Cells are treated with compound concentrations ranging from 0.1 to 100 µM for 24-72 hours. Lipid peroxidation is measured by assessing MDA levels or by using fluorescent probes such as C11-BODIPY581/591. Cell viability is assessed using MTT or CCK-8 assays.
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| Animal Protocol |
In vivo animal studies for Pinocembrin 7-O-Beta-D-Glucoside would typically utilize rodent models of oxidative stress or metabolic disorders. The compound is administered orally or intraperitoneally. Endpoints include markers of lipid peroxidation in serum and tissues (MDA, 8-isoprostane), antioxidant enzyme activities (SOD, CAT, GPx), and histopathological evaluation of oxidative damage in target organs.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Pinocembrin 7-O-Beta-D-Glucoside are not well characterized. The compound has a molecular weight of 418.39 and a molecular formula of C₂₁H₂₂O₉. As a flavonoid glycoside, it is expected to have limited oral bioavailability due to poor membrane permeability and extensive first-pass metabolism. The glycoside moiety may be hydrolyzed by intestinal glycosidases, releasing the aglycone pinocembrin.
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| Toxicity/Toxicokinetics |
Toxicological data for Pinocembrin 7-O-Beta-D-Glucoside are limited. As a naturally occurring flavonoid glycoside, it is expected to have a favorable safety profile. No significant acute toxicity has been reported. The compound is designated for research use only.
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| References | |
| Additional Infomation |
Pinus 2-7-OD-glucoside has been reported to have been found in mistletoe, mulberry mistletoe, and other organisms with available data.
Pinocembrin 7-O-Beta-D-Glucoside is a flavonoid glycoside that enhances lipid peroxidation. It has a molecular weight of 418.39 and formula C₂₁H₂₂O₉. It is derived from natural sources such as Penthorum chinense and Viscum articulatum. It is not clinically approved and is used as a research tool for oxidative stress studies. |
| Molecular Formula |
C21H22O9
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|---|---|
| Molecular Weight |
418.3940
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| Exact Mass |
418.126
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| CAS # |
75829-43-5
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| PubChem CID |
46881227
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| Appearance |
White to off-white solid powder
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| LogP |
0.9
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
30
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| Complexity |
595
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| Defined Atom Stereocenter Count |
6
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| SMILES |
C12OC(C3C=CC=CC=3)CC(=O)C=1C(=CC(=C2)OC1C(O)C(O)C(O)C(CO)O1)O
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| InChi Key |
GPGFGFUBECSNTG-SFTVRKLSSA-N
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| InChi Code |
InChI=1S/C21H22O9/c22-9-16-18(25)19(26)20(27)21(30-16)28-11-6-12(23)17-13(24)8-14(29-15(17)7-11)10-4-2-1-3-5-10/h1-7,14,16,18-23,25-27H,8-9H2/t14-,16+,18+,19-,20+,21+/m0/s1
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| Chemical Name |
(2S)-5-hydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydrochromen-4-one
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| Synonyms |
Pinocembrin41-O-β-D-glucosidePinocembrin 7-O-beta-D-glucosidePinocembrosidePonocembrin-7-O-β-D-glucopyranosidePinocembrin 7-O-β-D-glucoside
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~119.51 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | |
| 5 mM | 0.4780 mL | 2.3901 mL | 4.7802 mL | |
| 10 mM | 0.2390 mL | 1.1951 mL | 2.3901 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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