| Size | Price | Stock | Qty |
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| 5g |
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| 25g |
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| Other Sizes |
| Targets |
Pimelic acid is an endogenous metabolite involved in fatty acid metabolism. As a dicarboxylic acid, it is a substrate for various metabolic enzymes and participates in the β-oxidation pathway. The compound is a component of the fatty acid biosynthesis pathway and serves as a precursor for the synthesis of other biochemicals. It is also used in industrial applications as a building block for polymers and other chemical products.
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| ln Vitro |
In vitro, pimelic acid is used as a research chemical and metabolic intermediate. It is a substrate for enzymes involved in fatty acid oxidation and metabolism. The compound's effects on cellular metabolism can be studied in cell culture models. As a dicarboxylic acid, it may affect cellular pH and metabolic pathways. It is also used as a reference standard in analytical chemistry.
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| ln Vivo |
In vivo, pimelic acid is an endogenous metabolite produced by ω-oxidation and β-oxidation of fatty acids in the body. It is found in animal tissues and urine. The compound is involved in normal fatty acid metabolism and serves as a metabolic intermediate. Its presence in biological fluids reflects fatty acid metabolism. The compound is also used in nutritional and metabolic studies.
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| Enzyme Assay |
For non-cell enzyme/receptor binding assays, pimelic acid can be studied for its interactions with metabolic enzymes. Enzyme activity assays using fatty acid oxidation enzymes can be performed. The compound's role as a substrate or inhibitor in metabolic pathways can be assessed. Its acid-base properties and metal-chelating abilities can also be studied in biochemical assays. The compound is used as a reference standard for analytical method development.
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| Cell Assay |
For in vitro cell-based assays, pimelic acid can be tested in cell culture models to study its effects on cellular metabolism. Cells are treated with the compound, and metabolic parameters are measured. The compound's effects on fatty acid oxidation and energy metabolism can be assessed. Its potential effects on cell viability and proliferation can also be studied. The compound is used as a tool to study metabolic pathways in cell culture.
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| Animal Protocol |
For in vivo animal experiments, pimelic acid can be administered to animals to study its metabolism and effects on fatty acid oxidation. The compound can be used as a metabolic tracer or substrate to study fatty acid metabolism pathways. Its effects on metabolic parameters and tissue distribution can be assessed. The compound's role in energy metabolism and fatty acid β-oxidation can be studied in animal models.
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| ADME/Pharmacokinetics |
Pimelic acid has a molecular weight of 160.17 g/mol and molecular formula C₇H₁₂O₄. It appears as colorless monoclinic prism crystals with a density of 1.329 g/mL at 20°C. The compound is soluble in ethanol, ether, and water (2.52 parts per 100 parts at 13.5°C), and soluble in acetone. It is almost insoluble in benzene. The compound can sublime and has a low toxicity profile.
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| Toxicity/Toxicokinetics |
Pimelic acid is considered to have low toxicity. It is an endogenous metabolite and is naturally present in the body. No significant toxicity has been reported at physiological concentrations. The compound is used in industrial applications and as a research chemical. Standard safety precautions for handling organic acids should be followed. The compound is not used as a pharmaceutical drug.
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| Additional Infomation |
Pimelic acid is an α,ω-dicarboxylic acid with a pentane structure, consisting of two carboxylic acid groups attached at the C-1 and C-5 positions, respectively. It is found in Escherichia coli and Leptochloa crus-galli, and is an α,ω-dicarboxylic acid and a dicarboxylic acid fatty acid. It is the conjugate acid of pimelic acid and pimelic acid(1-). Pimelic acid has been reported to be found in Bruchwegia brevis, Arabidopsis thaliana, and other organisms with relevant data. Pimelic acid is a class of compounds with the general formula R-C7H11O4.
Pimelic acid (heptanedioic acid) is a seven-carbon saturated dicarboxylic acid that is an endogenous metabolite produced by fatty acid oxidation. It was first isolated from castor oil in 1884 and from bovine urine in 1937. The compound is used in industrial applications as a building block for polymers, plasticizers, and lubricants. It is also used as a research chemical in metabolic studies. The compound is not a pharmaceutical drug and has no clinical applications. |
| Molecular Formula |
C7H12O4
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|---|---|
| Molecular Weight |
160.1678
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| Exact Mass |
160.073
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| CAS # |
111-16-0
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| Related CAS # |
Pimelic acid-d4;19031-56-2
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| PubChem CID |
385
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
353.7±25.0 °C at 760 mmHg
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| Melting Point |
103-105 °C(lit.)
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| Flash Point |
181.9±19.7 °C
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| Vapour Pressure |
0.0±1.7 mmHg at 25°C
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| Index of Refraction |
1.476
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| LogP |
0.27
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
11
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| Complexity |
125
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
WLJVNTCWHIRURA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H12O4/c8-6(9)4-2-1-3-5-7(10)11/h1-5H2,(H,8,9)(H,10,11)
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| Chemical Name |
heptanedioic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~110 mg/mL (~686.77 mM)
H2O : ~110 mg/mL (~686.77 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (17.17 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (17.17 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.2434 mL | 31.2168 mL | 62.4337 mL | |
| 5 mM | 1.2487 mL | 6.2434 mL | 12.4867 mL | |
| 10 mM | 0.6243 mL | 3.1217 mL | 6.2434 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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