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    Pifithrin-μ (NSC-303580)
    Pifithrin-μ (NSC-303580)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0020
    CAS #: 64984-31-2Purity ≥98%

    Description: Pifithrin-μ (NSC303580) is a novel and potent inhibitor of p53 binding and p53-mediated apoptosis with a Kd of 0.82 mM in vitro. It has antitumor and neuroprotective activity. 

    References: J Biol Chem. 2010 Jan 29;285(5):3439-50.

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    Molecular Weight (MW)181.21
    FormulaC8H7NO2S
    CAS No.64984-31-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 36 mg/mL (198.7 mM)
    Water: <1 mg/mL (slightly soluble or insoluble)
    Ethanol: N/A
    Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80:10 mg/mL
    SynonymsPifithrin-µ; Pifithrin µ; Pifithrinµ; 2-Phenylethynesulfonamide; PFT-µ; PFT µ; PFTµ; NSC303580; NSC-303580; NSC 303580


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    GeneralPifithrin-μ (40 mg/kg, ip) produces protective effect from p53-dependent apoptosis in C57B1/6J mice of 8 or 9 Gy of total body gamma radiation. In a xenograft mouse model, Pifithrin-μ significantly enhances the inhibition of TRAIL on MiaPaca-2 tumor growth
    Animal model C57B1/6J mice.
    Formulation DMSO
    Dosages 40 mg/kg
    Administration i.p
    References[1] Strom E, et al. Nat Chem Biol. 2006, 2(9), 474-479.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Pifithrin-μ
    Blood Cancer J. 2011 Jul; 1(7): e28.
     

    Pifithrin-μ



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