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    Pifithrin-α (PFTα)
    Pifithrin-α (PFTα)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0014
    CAS #: 63208-82-2Purity ≥98%

    Description: Pifithrin-α ((PFTα) is a novel and potent inhibitor of p53, acting by inhibiting p53 protein transcription and p53-dependent transactivation of p53-responsive genes. It also acts as an aryl hydrocarbon receptor (AhR) agonist. Pifithrin-α was firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. Pifithrin-α can also induce cell cycle arrest and growth arrest of embryonic stem cells. Treatment of Pifithrin-α significantly downregulates the protein lever of Nanog (a pluripotency marker). It is proved that the inhibition of p53 activity caused by Pifithrin-α has no effect on ES cell viability.

    Reference: Science. 1999 Sep 10;285(5434):1733-7.

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    Molecular Weight (MW)367.3
    FormulaC16H18N2OS.HBr
    CAS No.63208-82-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 67 mg/mL (182.41 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 2 mg/mL (6.08 mM)
    Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
    SMILES CodeCC1=CC=C(C(CN2C(SC3=C2CCCC3)=N)=O)C=C1.[H]Br
    SynonymsPifithrin-alpha; Pifithrin alpha; PFTalpha; PFTalpha; PFT alpha


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    GeneralPifithrin-α (2.2 mg/kg i.p.) treatment completely rescues mice (C57BL and Balb/c) of both strains from 60% killing doses of gamma irradiation (8 Gy for C57BL and 6 Gy for Balb/c). Pifithrin-α-injected mice lost less weight than irradiated mice that are not pretreated with the Pifithrin-α. Pifithrin-α (2.2 mg/kg) abrogates p53-dependent regulation of DNA replication after whole-body gamma irradiation in mice.
    Animal modelC57BL and Balb/c mice
    FormulationDissolved in Saline
    Dosages2.2 mg/kg
    Administrationi.p
    References[1] Komarov PG, et al. Science, 1999, 285(5434), 1733-1737.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Pifithrin-α (PFTα)
    IS upregulates α-SMA protein through p53 and ROS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.
     
    Pifithrin-α (PFTα)
    IS induces activated p53 expression, which is involved in suppression of serum-induced proliferation of HK-2 cells caused by IS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.
     
    Pifithrin-α (PFTα)
    IS-induced HK-2 cell senescence is inhibited by PFTα. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.


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