Fibroblasts exhibit a sensitivity of 150 μM to soy phosphatidylcholine liposomes [3].

Effects During Pregnancy and Lactation
◉ Overview of Lactation Use
Lecithin is a mixture of choline, choline esters, fatty acids, glycerol, glycolipids, triglycerides, phosphoric acid, and phospholipids (such as phosphatidylcholine), all normal components of human milk. Lecithin supplementation has been recommended for treating blocked milk ducts and as an additive pumped into breast milk through plastic tubes to prevent fat loss in premature infants. Currently, there are no scientifically valid clinical studies on the safety and efficacy of high-dose lecithin supplementation for breastfeeding mothers or infants. Most breastfeeding mothers have insufficient choline intake, and the choline content in the breast milk of extremely premature infants may be reduced. One component of lecithin supplementation—phosphatidylcholine—can increase the concentration of choline in breast milk but does not increase the concentration of phosphatidylcholine; conversely, choline supplementation can increase the concentration of choline metabolites in breast milk but does not increase the concentration of choline. A meta-analysis found that higher maternal choline intake may be associated with better neurocognitive and neurodevelopmental development in children. Lecithin is generally well-tolerated and is recognized as “Generally Recognized As Safe” (GRAS) by the U.S. Food and Drug Administration (FDA). Dietary supplements do not require extensive premarket approval from the FDA. Manufacturers are responsible for ensuring the safety of their products but are not required to prove their safety and efficacy before marketing them. Dietary supplements may contain multiple ingredients, and there are often differences between the ingredients listed on the label and the actual ingredients or amounts. Manufacturers may commission independent organizations to verify the quality of their products or their ingredients, but this does not necessarily mean that the product has been certified as safe or effective. Given the above issues, clinical trial results for one product may not apply to other products. For more detailed information on dietary supplements, please visit other pages on the LactMed website.
◉ Effects on breastfed infants
No published information found as of the revision date.
◉ Effects on lactation and breast milk
No published information found as of the revision date.

[1]. Soybean phosphatidylcholine liposomes as model membranes to study lipid peroxidation photoinduced by pterin. Biochim Biophys Acta. 2016 Jan;1858(1):139-45.

[2]. Doxorubicin biocompatible O/W microemulsion stabilized by mixed surfactant containing soya phosphatidylcholine. Colloids Surf B Biointerfaces. 2006 Aug 1;51(1):54-61.

[3]. Comparison of the effects of dimyristoyl and soya phosphatidylcholine liposomes on human fibroblasts. Drug Deliv. 2000 Jan-Mar;7(1):37-44.

PC (16:0/18:2(9E,12E)) is a 1,2-diacyl-sn-glycerol-3-phosphocholine. Phospholipids are complex mixtures containing phospholipids, glycolipids, triglycerides, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Lecithin is a phospholipid whose polar choline is linked to diacylglycerols via phosphate ester bonds. Phospholipids are complex mixtures containing phospholipids, glycolipids, and triglycerides, as well as significant amounts of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol, which are sometimes collectively referred to as 1,2-diacyl-3-phosphocholine. Lecithin is a component of cell membranes and can be extracted from soybeans and egg yolks. Its emulsifying and surfactant properties make it suitable for use as a food additive and in the preparation of organic gels (gels).

C42H80NO8P

758.0603

757.562

97281-47-5

16213884

Colorless to light yellow ointment

236-237 °C

10.9

0

8

40

52

941

1

CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC

JLPULHDHAOZNQI-JLOPVYAASA-N

InChI=1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14+,21-20+/t40-/m1/s1

[(2R)-3-hexadecanoyloxy-2-[(9E,12E)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Ethanol :≥ 100 mg/mL
DMSO : ~10 mg/mL

Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 900 μL of corn oil and mix evenly.

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Solubility in Formulation 3: 1 mg/mL (Infinity mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.

Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 4: ≥ 1 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)