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    PF-5190457
    PF-5190457

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4451
    CAS #: 1334782-79-4Purity ≥98%

    Description: PF-5190457 is a novel, potent, orally available and selective ghrelin receptor inverse agonist with a pKi of 8.36. PF-5190457 potently increases insulin secretion in glucose-stimulated human islets. PF-5190457 has a superior balance of ghrelin receptor pharmacology and off-target selectivity. On the basis of its promising pharmacological and safety profile, PF-5190457 was advanced to human clinical trials.

    References:  2014 Feb 24;5(5):474-9. 


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    PF-5190457

    Name: PF-5190457
    CAS#: 1334782-79-4
    Chemical Formula: C29H32N6OS
    Exact Mass: 512.23583
    Molecular Weight: 512.676
    Elemental Analysis: C, 67.94; H, 6.29; N, 16.39; O, 3.12; S, 6.25
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-5190457; PF 5190457; PF5190457; PF-05190457; PF05190457; PF 05190457.
    IUPAC/Chemical Name: (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one
    InChi Key: ZIUDADZJCKGWKR-AREMUKBSSA-N
    InChi Code: InChI=1S/C29H32N6OS/c1-19-11-25(31-18-30-19)22-3-5-24-21(12-22)4-6-26(24)35-16-29(17-35)7-9-33(10-8-29)27(36)13-23-15-34-14-20(2)37-28(34)32-23/h3,5,11-12,14-15,18,26H,4,6-10,13,16-17H2,1-2H3/t26-/m1/s1
    SMILES Code: CC1=CC(C2=CC3=C([[email protected]](N4CC5(CCN(C(CC(N=C6S7)=CN6C=C7C)=O)CC5)C4)CC3)C=C2)=NC=N1


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