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    PF-06726304
    PF-06726304

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4563
    CAS #: 1616287-82-1Purity ≥98%

    Description: PF-06726304 is a novel, potent and selective SAM-competitive EZH2 (enhancer of zeste homolog 2) inhibitor with a Ki of 0.7 nM. PF-06726304 displayed improved LipE and on-target potency in both biochemical and cellular readouts relative to compound 18. PF-06726304 also displayed robust in vivo antitumor growth activity and dose-dependent de-repression of EZH2 target genes.

    References 2016 Sep 22;59(18):8306-25.


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    PF-06726304

    Name: PF-06726304
    CAS#: 1616287-82-1
    Chemical Formula: C22H21Cl2N3O3
    Exact Mass: 445.096
    Molecular Weight: 446.328
    Elemental Analysis: C, 59.20; H, 4.74; Cl, 15.89; N, 9.41; O, 10.75
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-6726304; PF 6726304; PF6726304; PF-06726304; PF 06726304; PF06726304;
    IUPAC/Chemical Name: 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone
    InChi Key: PDKDOPJQPKXNCT-UHFFFAOYSA-N
    InChi Code: InChI=1S/C22H21Cl2N3O3/c1-10-7-11(2)25-21(28)16(10)9-27-6-5-14-17(23)8-15(20(24)19(14)22(27)29)18-12(3)26-30-13(18)4/h7-8H,5-6,9H2,1-4H3,(H,25,28)
    SMILES Code: O=C1N(CC2=C(C)C=C(C)NC2=O)CCC3=C1C(Cl)=C(C4=C(C)ON=C4C)C=C3Cl


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