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    PF-06465469
    PF-06465469

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4445
    CAS #: 1407966-77-1 Purity ≥98%

    Description: PF-06465469 is a novel, potent and covalent inhibitor of ITK (IL-2 inducible T-cell kinase) with an IC50 of 2 nM. ITK is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells.  

    References:  2018 Sep 21;8(1):14216. 


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    PF-06465469

    Name: PF-06465469
    CAS#: 1407966-77-1
    Chemical Formula: C30H33N7O2
    Exact Mass: 523.2696
    Molecular Weight: 523.641
    Elemental Analysis: C, 68.81; H, 6.35; N, 18.72; O, 6.11
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-6465469; PF 6465469; PF6465469; PF-06465469; PF 06465469; PF06465469
    IUPAC/Chemical Name: 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
    InChi Key: CGJVMKJGKFEHTL-HSZRJFAPSA-N
    InChi Code: InChI=1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1
    SMILES Code: O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([[email protected]]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2


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