| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
In the conditioned media of human lung epithelial cells (A549) activated with TNF-α (20 ng/mL) or IL-1β (10 ng/mL), there is a powerful PMN chemokine called peptide 78. With 78 amino acids and an 8.3 kDa molecular weight, peptide 78 shares four cysteines with IL-8 and its homologs. Platelet factor 4, platelet basic protein, and the products of its cleavage (connective tissue activating peptide-III, β-thromboglobulin and interferon-γ-induced protein, macrophage inflammatory protein-2α, and macrophage inflammatory protein-2α) are among the supergene family of which peptide 78 is a member. Inflammatory protein-2β) phagocytosis) [1]. Peptide 78, like NAP-2 or LL-8, possesses a number of PMN-activating characteristics. Peptide 78 stimulated PMNs in a way that resulted in considerable chemotactic activity, the release of free cytosolic calcium, and the release of elastase from cells that had been pretreated with cytochalasin B. PMN recruitment to RA-inflamed joints is aided by peptide 78. One of the most prevalent chemokines found in RA synovial fluid is peptide 78. The physiologically active peptide 78 is found in rheumatoid arthritis synovial fluid. About half of the RA synovial fluid PMN's in vitro chemotactic activity appears to be accounted for by peptide 78 [1].
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| References |
| Molecular Formula |
C60H106N22O20S
|
|---|---|
| Molecular Weight |
1487.7
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| Exact Mass |
1541.773
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| CAS # |
132116-62-2
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| PubChem CID |
3081257
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| Appearance |
White to off-white solid powder
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| Density |
1.6±0.1 g/cm3
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| Index of Refraction |
1.685
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| LogP |
-5.09
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| Hydrogen Bond Donor Count |
23
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| Hydrogen Bond Acceptor Count |
26
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| Rotatable Bond Count |
49
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| Heavy Atom Count |
107
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| Complexity |
3200
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| Defined Atom Stereocenter Count |
14
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| SMILES |
C[C@H]([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)O)N)O
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| InChi Key |
BNIFSVVAHBLNTN-XKKUQSFHSA-N
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| InChi Code |
InChI=1S/C62H107N23O21S/c1-29(2)47(57(102)74-30(3)48(93)81-38(60(105)106)25-43(65)89)83-53(98)36(26-45(91)92)80-55(100)41-16-11-22-85(41)59(104)37(24-42(64)88)75-44(90)27-73-49(94)39(28-86)82-51(96)33(14-9-20-72-62(69)70)77-54(99)40-15-10-21-84(40)58(103)35(12-6-7-18-63)79-50(95)32(13-8-19-71-61(67)68)76-52(97)34(17-23-107-5)78-56(101)46(66)31(4)87/h29-41,46-47,86-87H,6-28,63,66H2,1-5H3,(H2,64,88)(H2,65,89)(H,73,94)(H,74,102)(H,75,90)(H,76,97)(H,77,99)(H,78,101)(H,79,95)(H,80,100)(H,81,93)(H,82,96)(H,83,98)(H,91,92)(H,105,106)(H4,67,68,71)(H4,69,70,72)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,46-,47-/m0/s1
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| Chemical Name |
(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
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| Synonyms |
Peptide78; Peptide-78; Peptide 78
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~64.82 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (64.82 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.6722 mL | 3.3609 mL | 6.7218 mL | |
| 5 mM | 0.1344 mL | 0.6722 mL | 1.3444 mL | |
| 10 mM | 0.0672 mL | 0.3361 mL | 0.6722 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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