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    BMS-1
    BMS-1

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3097
    CAS #: 1675201-83-8Purity ≥98%

    Description: BMS-1 (also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) is a novel and highly potent small molecule inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 nM. It was first discovered by BMS (Bristol-Myers-Squibb) as an immunomodulator for the Programmed death-ligand 1 (PD-L1) with potential anticancer activities. PD-L1 is known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It is reported that the overexpression of PD-L1 may allow cancers to escape the surveilance of host immune system.

    References: WO/2015/034820 2017 Jul 13;60(13):5857-5867.


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    Molecular Weight (MW) 475.58
    Formula C29H33NO5
    CAS No. 1675201-83-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 95 mg/mL (199.7 mM)
    Water: 95 mg/mL (199.7 mM)
    Ethanol: N/A
    SMILES CodeO=C([[email protected]]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O
    SynonymsPD1/PDL1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD1-PDL1-IN1; BMS-1; BMS 1; BMS1


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    In Vitro

    In vitro activity: PD1-PDL1 inhibitor 1 (also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) is a small molecule inhibitor of PD-1/PD-L1 protein/protein interaction with IC50 of 6 nM. It was first discovered by BMS (Bristol-Myers-Squibb) as an immunomodulator for the Programmed death-ligand 1 (PD-L1) with potential anticancer activities. PD-L1 is known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It is reported that the overexpression of PD-L1 may allow cancers to escape the surveilance of host immune system.


    Kinase Assay: The HTRF PD1/PD-L1 Binding Assay is designed to measure the interaction between PD1 and PD-L1 proteins. Utilizing HTRF (Homogeneous Time-resolved Fluorescence) technology, the assay enables simple and rapid characterization of compound and antibody blockers in a high throughput format.

    In VivoNA
    Animal modelNA
    Formulation & DosageNA
    References  2017 Jul 13;60(13):5857-5867. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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