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    PD-1/PD-L1 Inhibitor 3
    PD-1/PD-L1 Inhibitor 3

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2653
    CAS #: 1629654-95-0Purity ≥98%

    Description: PD-1/PD-L1 Inhibitor 3 is a macrocyclic inhibitor of PD-1/PD-L1 protein-protein interaction. It has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1) and with CD80. PD-1/PD-L1 inhibitor 3 was also found to act as an immunomodulator. In addition, PD-1/PD-L1 Inhibitor 3 was found to have highly efficacious binding to PD-L1 and promote the increased functional activities of T cells. Therefore, PD-1/PD-L1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis C.

    References: Patent, Pub. No.:WO/2014/151634


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    Molecular Weight (MW)1852.17 
    FormulaC89H126N24O18S 
    CAS No.1629654-95-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (54 mM) 
    Water: <1 mg/mL
    Ethanol: 100 mg/mL (54 mM) 
    Solubility (In vivo)
    Synonyms


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    In Vitro

    In vitro activity: PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity. PD-1/PD-L1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1) and with CD80. PD-1/PD-L1 inhibitor 3 was also found to act as an immunomodulator. In addition, PD-1/PD-L1 Inhibitor 3 was found to have highly efficacious binding to PD-L1 and promote the increased functional activities of T cells. Therefore, PD-1/PD-L1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis C


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    References

    Patent, Pub. No.:WO/2014/151634 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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