| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
|
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| Other Sizes |
| Targets |
- Oxfendazole exerts anthelmintic effects by binding to parasitic β-tubulin, inhibiting microtubule polymerization and disrupting parasite cell division [1]
|
|---|---|
| ln Vitro |
- Oxfendazole inhibits hatching of gastrointestinal nematode eggs and development of larval stages in vitro, disrupting parasite cell structural integrity via microtubule targeting to induce larval death and reduce egg viability [1]
|
| ln Vivo |
- In naturally infected pigs, a single oral dose of Oxfendazole (30 mg/kg body weight) reduced fecal egg counts (FEC) by 95.6–100% for Ascaris suum and Oesophagostomum spp. 14 days post-administration; a 45 mg/kg dose achieved 100% FEC reduction for all tested gastrointestinal nematodes (including Trichuris suis) [2]
- In cattle (200–400 kg body weight) and sheep (40–60 kg body weight), oral Oxfendazole (5–10 mg/kg body weight) eliminated gastrointestinal nematodes (Haemonchus contortus, Teladorsagia circumcincta) and lungworms (Dictyocaulus viviparus), with >90% FEC reduction 7–10 days post-treatment [1] |
| Animal Protocol |
- For naturally infected pigs (2–4 months old, 15–25 kg body weight): 60 infected pigs were divided into 3 groups (control, 30 mg/kg Oxfendazole, 45 mg/kg Oxfendazole). The drug was given as an oral suspension mixed with feed. Fecal samples were collected on days 0, 7, 14 post-treatment for FEC; 5 pigs per group were euthanized on day 14 to dissect the gastrointestinal tract and count adult worms [2]
|
| ADME/Pharmacokinetics |
After oral administration, oxendazole is well absorbed and metabolized in the liver to the active metabolite oxendazole sulfone. In ruminants, the plasma half-life is 12-18 hours, and it is mainly excreted in feces (70-80%) and urine (20-30%).[1]
|
| Toxicity/Toxicokinetics |
- The median lethal dose (LD50) of orally administered oxifenedazol in rats was > 10 g/kg body weight; no hepatotoxicity or nephrotoxicity was observed at therapeutic doses [1]
|
| References | |
| Additional Infomation |
Olfendazole is a benzimidazole drug with a structure similar to fenbendazole, except that sulfur is oxidized to the corresponding sulfoxide. It is an anti-nematode drug. Olfendazole is a sulfoxide, belonging to the benzimidazole class of compounds, and is also a carbamate. It is functionally related to fenbendazole. Olfendazole is the sulfoxide metabolite of fenbendazole. This benzimidazole anthelmintic can protect livestock from roundworms, roundworms and nematodes. See also: Olfendazole; trichlorfon (one of the components). - Olfendazole is indicated for the treatment and control of gastrointestinal nematode and lungworm infections in livestock (cattle, sheep, pigs)[1] - The anthelmintic mechanism of oxendazole is to disrupt microtubule-dependent cellular processes to block the parasite's nutrient transport and reproductive functions[1]
|
| Molecular Formula |
C15H13N3O3S
|
|---|---|
| Molecular Weight |
315.3470
|
| Exact Mass |
315.067
|
| CAS # |
53716-50-0
|
| PubChem CID |
40854
|
| Appearance |
White to off-white solid powder
|
| Density |
1.5±0.1 g/cm3
|
| Melting Point |
253ºC
|
| Index of Refraction |
1.736
|
| LogP |
1.36
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
22
|
| Complexity |
428
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BEZZFPOZAYTVHN-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
|
| Chemical Name |
methyl N-[6-(benzenesulfinyl)-1H-benzimidazol-2-yl]carbamate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~31.25 mg/mL (~99.10 mM)
H2O : ~0.67 mg/mL (~2.12 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.60 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1711 mL | 15.8554 mL | 31.7108 mL | |
| 5 mM | 0.6342 mL | 3.1711 mL | 6.3422 mL | |
| 10 mM | 0.3171 mL | 1.5855 mL | 3.1711 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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