| Size | Price | Stock | Qty |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| Other Sizes |
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| ln Vitro |
Four clinical isolates of S. aureus that carry the mecA gene (SA 1306, SA 1326, SA 1552, and SA 4666) show MIC values of less than 1 μg/mL for oxacillin[1].
Tol+ and Tol-strains undergo lysis when exposed to oxacillin (5 μg/mL) for 0-90 min[2]. |
|---|---|
| Cell Assay |
Cell Line: Cells of S. aureus which had grown for six to eight generations in [14C]glycerol.
Concentration: 5 μg/mL. Incubation Time: 0, 30, 60, 90 min. Result: The rates at which the cells lysed allowed for the easy separation of Tol+ isolates from Tol- isolates. |
| References | |
| Additional Infomation |
Oxacillin sodium monohydrate is a hydrate. It contains an oxacillin sodium.
Oxacillin Sodium is the sodium salt form of oxacillin, a semisynthetic penicillinase-resistant and acid-stable penicillin with an antimicrobial activity. Oxacillin binds to penicillin-binding proteins in the bacterial cell wall, thereby blocking the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This leads to inhibition of cell growth and causes cell lysis. An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. See also: Oxacillin Sodium (annotation moved to). |
| Molecular Formula |
C19H20N3NAO6S
|
|---|---|
| Molecular Weight |
441.4334
|
| Exact Mass |
441.097
|
| CAS # |
7240-38-2
|
| Related CAS # |
Oxacillin sodium salt;1173-88-2;Oxacillin;66-79-5
|
| PubChem CID |
23694213
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| Appearance |
Typically exists as solid at room temperature
|
| Boiling Point |
686.8ºC at 760 mmHg
|
| Melting Point |
188ºC
|
| Flash Point |
369.2ºC
|
| Index of Refraction |
205 ° (C=1, H2O)
|
| LogP |
0.992
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
30
|
| Complexity |
687
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
S1C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(C(=O)[O-])N2C([C@]([H])([C@@]12[H])N([H])C(C1=C(C([H])([H])[H])ON=C1C1C([H])=C([H])C([H])=C([H])C=1[H])=O)=O.[Na+].O([H])[H]
|
| InChi Key |
ZVIYWUUZWWBNMB-VICXVTCVSA-M
|
| InChi Code |
InChI=1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
|
| Chemical Name |
sodium;(2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
|
| Synonyms |
oxacillin sodium monohydrate; Oxacillin sodium hydrate; Bactocill; OXACILLIN SODIUM; Oxacillin sodium salt monohydrate; Cryptocillin; Penstapho
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~226.54 mM)
DMSO : ~50 mg/mL (~113.27 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 110 mg/mL (249.19 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2654 mL | 11.3268 mL | 22.6536 mL | |
| 5 mM | 0.4531 mL | 2.2654 mL | 4.5307 mL | |
| 10 mM | 0.2265 mL | 1.1327 mL | 2.2654 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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