| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
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| ln Vivo |
Potassium oxonate can be utilized in animal modeling to produce a high uric acid model.
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|---|---|
| References |
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| Additional Infomation |
Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.
Oteracil Potassium is the potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy. |
| Molecular Formula |
C4H2KN3O4
|
|---|---|
| Molecular Weight |
195.18
|
| Exact Mass |
194.968
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| CAS # |
2207-75-2
|
| PubChem CID |
2723920
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| Appearance |
White to off-white solid powder
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| Melting Point |
300 °C(lit.)
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
12
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| Complexity |
274
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
IAPCTXZQXAVYNG-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
|
| Chemical Name |
potassium;4,6-dioxo-1H-1,3,5-triazine-2-carboxylate
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| Synonyms |
Oxonate, potassium; Oxonic acid potassium salt; Oteracil potassium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~3.33 mg/mL (~17.06 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 9.09 mg/mL (46.57 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
Solubility in Formulation 2: 5 mg/mL (25.62 mM) in 0.5% CMC-Na/saline water (add these co-solvents sequentially from left to right, and one by one), suspension solution; with heating and sonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.1235 mL | 25.6174 mL | 51.2348 mL | |
| 5 mM | 1.0247 mL | 5.1235 mL | 10.2470 mL | |
| 10 mM | 0.5123 mL | 2.5617 mL | 5.1235 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
None
CTID: jRCT2080220727
Phase: Status:
Date: 2009-04-30
Products are for research use only; We do not sell to patients
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