| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
Iadademstat diHClide is a KDM1A inhibitor that binds to the flavin adenine nucleotide (FAD) cofactor irreversibly to render KDM1A inactive. In assays of mixed lineage leukemia (MLL) translocated acute myeloid leukemia (AML) cell lines' differentiation and colony formation, iadademstat exhibits strong selectivity for KDM1A over MAO enzymes and strong selectivity for KDM1B. Unmatched subnanomolar biological activity. In MLL-AF9 cells, iadademstat induced the Cd11b differentiation marker in a time- and dose-dependent manner. Interestingly, this occurred before alterations in H3K4me2 levels. Iadademstat also affects other acute leukemia (AL) cell lines, while MLL-translocated cells are the most vulnerable [1].
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| ln Vivo |
Iadademstat prolongs survival in disseminated T-ALL models and decreases the development of AML tumors in mice and rat xenografts [1].
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| References |
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| Molecular Formula |
C15H23CLN2
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|---|---|
| Molecular Weight |
266.809522867203
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| Exact Mass |
302.131
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| CAS # |
1431303-72-8
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| Related CAS # |
1431303-72-8 (2HCl);1431304-21-0;1431303-71-7 (xHCl);1431326-61-2 (2HCl);
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| PubChem CID |
71664305
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
239
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1CC(CCC1N)N[C@@H]2C[C@H]2C3=CC=CC=C3.Cl.Cl
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| InChi Key |
UCINOBZMLCREGM-RNNUGBGQSA-N
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| InChi Code |
InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1
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| Chemical Name |
4-N-[(1R,2S)-2-phenylcyclopropyl]cyclohexane-1,4-diamine;dihydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~57.75 mg/mL (~190.42 mM)
DMSO : ~0.69 mg/mL (~2.28 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (329.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7480 mL | 18.7399 mL | 37.4799 mL | |
| 5 mM | 0.7496 mL | 3.7480 mL | 7.4960 mL | |
| 10 mM | 0.3748 mL | 1.8740 mL | 3.7480 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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