| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Triptolide is a traditional Chinese medicine that has pro-apoptotic, anti-inflammatory, and anti-proliferative effects [1].
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| ln Vivo |
Oreprolactone significantly reduced blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) scores in the cisplatin-induced AKI animal model; however, tubular apoptosis scores did not significantly decrease. Boost. Oraprolactone has a protective effect against AKI that is linked to p-ERK decrease and is not influenced by pro-inflammatory cytokines or MKP-1 [1]. Oreprolactone was found to decrease airway blockage and limit the buildup of inflammatory cells in a mouse model of obstructive airway disease using an ectopic tracheal allograft. This suggests that oreprolactone may have therapeutic or preventive benefits for individuals with obstructive airway disease who have had lung transplantation. therapeutic advantages [2]. When oraprolactone was given on the same day or five days after bleomycin, it prevented fibrosis in the bleomycin group. Additionally, omtriptolide dramatically decreased the myofibroblast count in the group that received bleomycin treatment [3]. When Vbeta3+ cell expansion is in the logarithmic phase (postoperative day 3), omtriptolide inhibits the expansion of CD4+Vbeta3+ and CD8+Vbeta3+ T cells (alloreactive T cells in this paradigm) in the spleen in vivo. They arrived at 64.09% and 34.02%, respectively. transplant) [4].
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| References |
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| Molecular Formula |
C24H28O9
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|---|---|
| Molecular Weight |
460.479
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| Exact Mass |
460.173
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| CAS # |
195883-06-8
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| PubChem CID |
6918522
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| Appearance |
White to off-white solid powder
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| Density |
1.49
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| Melting Point |
109-111ºC
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| LogP |
1.518
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
33
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| Complexity |
1050
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| Defined Atom Stereocenter Count |
9
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| SMILES |
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2OC(=O)CCC(=O)O)O7)COC6=O)C
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| InChi Key |
HROMYAWHLUOUPY-AHCCQAQQSA-N
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| InChi Code |
InChI=1S/C24H28O9/c1-10(2)22-17(32-22)18-24(33-18)21(3)7-6-11-12(9-29-19(11)28)13(21)8-14-23(24,31-14)20(22)30-16(27)5-4-15(25)26/h10,13-14,17-18,20H,4-9H2,1-3H3,(H,25,26)/t13-,14-,17-,18-,20+,21-,22-,23+,24+/m0/s1
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| Chemical Name |
4-[[(1S,2S,4S,5S,7S,8R,9R,11S,13S)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl]oxy]-4-oxobutanoic acid
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| Synonyms |
PG-490-88; PG490-88
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~1.39 mg/mL (~3.02 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 3.33 mg/mL (7.23 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1716 mL | 10.8582 mL | 21.7165 mL | |
| 5 mM | 0.4343 mL | 2.1716 mL | 4.3433 mL | |
| 10 mM | 0.2172 mL | 1.0858 mL | 2.1716 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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