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    OG-L002
    OG-L002

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0370
    CAS #: 1357302-64-7Purity ≥98%

    Description: OG-L002 (OG-L-002) is a pecific inhibitor of LSD-1 [ lysine (K)-specific demethylase 1A] with potential antiviral activity. It inhibits LSD-1 with an IC50 of 20 nM in a cell-free assay, and displays 36- and 69-fold selectivity for LSD-1 over MAO-B and MAO-A, respectively. OG-L002 shows potent in vitro antiviral activity and high in vivo efficacy. It was foud to inhibit herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro and suppresses HSV primary infection in vivo.

    References: Nature. 2012 Aug 16;488(7411):404; Trends Cell Biol. 2010 Nov;20(11):662-71.

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    Molecular Weight (MW)225.29
    FormulaC15H15NO
    CAS No.1357302-64-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 45 mg/mL (199.7 mM)
    Water: <1 mg/mL
    Ethanol: 45 mg/mL (199.7 mM)
    Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 20 mg/mL
    Synonyms

    OGL002; OGL 002; OG-L002

    Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol

    InChi Key: DSOJSZXQRJGBCW-CABCVRRESA-N

    InChi Code: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m1/s1

    SMILES Code: OC1=CC(C2=CC=C([[email protected]@H]3[[email protected]@H](N)C3)C=C2)=CC=C1 


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    In Vitro

    In vitro activity: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene


    Kinase Assay: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene


    Cell Assay:  HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control.

    In VivoOG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.
    Animal modelBALB/c female mice are infected with HSV-2 (strain MS).
    Formulation & DosageDissolved in DMSO; 50 mg/kg; i.p.
    References

    Nature. 2012 Aug 16;488(7411):404; Trends Cell Biol. 2010 Nov;20(11):662-71.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    OG-L002

    Treatment of mice with OG-L002 reduces HSV primary infection in vivo. MBio. 2013 Feb 5;4(1):e00558-12


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