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    OF-1 (OF-1)
    OF-1 (OF-1)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0420
    CAS #: 919973-83-4Purity ≥98%

    Description: OF-1 (OF1; SGC-OF-1) is a potent and selective inhibitor of bromodomain and PHD finger containing protein 1 (BRPF1) with important biological activity. It inhibits BRPF1B and BRPF2 bromodomain with Kds of 100 nM and 500 nM, respectively. BRPF (BRomodomain and PHD Finger containing) protein family are scaffolding proteins that assembles MYST histone acetyltransferase complexes. MYST complexes play important role in DNA repair, recombination, replication and transcription activation.


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    • 香港大学
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    Molecular Weight (MW)440.31
    CAS No.919973-83-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 76 mg/mL (172.6 mM)
    Water: <1 mg/mL
    Ethanol:  <1 mg/mL
    Other info

    Chemical Name: 4-Bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-2-methyl-benzenesulfonamide


    InChi Code: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3

    SMILES Code: O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O

    SynonymsOF-1; SGC OF 1; SGC OF1; SGC OF-1; SGCOF1; SGC-OF-1; 

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    In Vitro

    In vitro activity: As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity.

    Kinase Assay: OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor with Kd values of 100 nM/500 nM for BRPF1B/BRPF2; 39-fold selectivity over BRD4.

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    Formulation & Dosage

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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