| Size | Price | Stock | Qty |
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| 25g |
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| 50g |
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| 100g |
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Octocrylene is an organic compound used as a UV (ultraviolet) filter in sunscreens and cosmetics to protect cosmetic formulations from UV radiation. It stabilizes the full-spectrum UVA blocker avobenzone to UV radiation, and absorbs mainly UVB radiation and short UVA wavelengths. Octocrylene or octocrilene is used in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation.
| References |
[1]Int J Environ Res Public Health. 2022 May 16;19(10):6037 |
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| Additional Infomation |
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate is a yellow, viscous liquid, insoluble in water. (NTP, 1992) Octocrylene is a diarylmethane. Octocrylene is a compound commonly used as an additive in sunscreens, believed to have moisturizing properties due to its skin-softening effects. This chemical is a common additive in sunscreens because it neutralizes ultraviolet radiation from sunlight and minimizes damage to the skin caused by prolonged sun exposure. Octocrylene is also frequently used in combination with avobenzone (another common sunscreen ingredient, often found on ingredient labels). Due to its effectiveness, this chemical is approved for use in cosmetics and skincare products worldwide, but its concentration is typically limited to 10% or 12%. However, the use of this chemical is not limited to sunscreens for the face and arms; it can be extended to various other products such as hairspray, tannin oil, BB cream, conditioner, and CC cream. Octocrylene may cause contact sensitization and photosensitivity. See also: Avobenzone; Ekachenox; Octocrylene (ingredient); Avobenzone; Octocrylene (ingredient); Octyl salicylate; Octocrylene (ingredient)... See more...
Drug Indications In the United States, octocrylene has been evaluated by the FDA and is considered safe for use at concentrations not exceeding 10% in formulations. Similarly, the European Union allows it at concentrations not exceeding 10% in formulations, while Health Canada allows a maximum usage concentration of 12%. Mechanism of Action Octocrylene is an effective oil-soluble liquid UVB filter. It has excellent properties for dissolving crystalline ultraviolet filters. Due to its excellent photostability, it is used as a photostable agent. The conjugated acrylate moiety absorbs UVB and short-wave UVA (ultraviolet light) wavelengths in the 280-320 nm range, thus protecting the skin from direct DNA damage. The ethylhexanol moiety is a fatty alcohol that, due to its hydrophobicity, can be used as a emollient. |
| Molecular Formula |
C24H27NO2
|
|---|---|
| Molecular Weight |
361.4767
|
| Exact Mass |
361.204
|
| CAS # |
6197-30-4
|
| PubChem CID |
22571
|
| Appearance |
Light yellow to yellow ointment
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| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
478.5±33.0 °C at 760 mmHg
|
| Melting Point |
−10 °C(lit.)
|
| Flash Point |
239.5±12.1 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.546
|
| LogP |
7.53
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
27
|
| Complexity |
510
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C(/C(/C#N)=C(\C1C([H])=C([H])C([H])=C([H])C=1[H])/C1C([H])=C([H])C([H])=C([H])C=1[H])=O)C([H])([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
FMJSMJQBSVNSBF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C24H27NO2/c1-3-5-12-19(4-2)18-27-24(26)22(17-25)23(20-13-8-6-9-14-20)21-15-10-7-11-16-21/h6-11,13-16,19H,3-5,12,18H2,1-2H3
|
| Chemical Name |
2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~276.64 mM)
Ethanol : ~50 mg/mL (~138.32 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (6.92 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7664 mL | 13.8320 mL | 27.6640 mL | |
| 5 mM | 0.5533 mL | 2.7664 mL | 5.5328 mL | |
| 10 mM | 0.2766 mL | 1.3832 mL | 2.7664 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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