| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
Purity: ≥98%
Octisalate is an organic chemical compound used in sunscreens and cosmetics to absorb the full range of UVB rays from the sun. Octisalate absorbs ultraviolet radiation in the UVB range and can protect from skin damage.
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
For local use only; no systemic absorption occurs. For local use only; no systemic absorption occurs. For local use only; no systemic absorption occurs. For local use only; no systemic absorption occurs. Metabolites/Metabolites For local use only; no systemic absorption occurs. Biological Half-Life For local use only; no systemic absorption occurs. |
|---|---|
| Toxicity/Toxicokinetics |
Protein Binding
This is for local use only and will not be absorbed systemically. |
| References |
N/A
|
| Additional Infomation |
Ethylhexyl salicylate is a benzoic acid ester, belonging to the phenolic compounds, and functions similarly to salicylic acid. It is also known as ethylhexyl salicylate. Octyl salicylate is an oil-soluble chemical sunscreen that absorbs UVB radiation but does not protect against UVA. Octyl salicylate is used to enhance the UVB protection of sunscreens. Salicylates have weak UVB absorption capacity and are usually used in combination with other UV filters. Octyl salicylate has good safety, with an effective wavelength range of 295-315 nm and a peak wavelength of 307-310 nm. It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light, protecting the skin from the harmful effects of sunlight, while the ethylhexanol portion acts as a emollient. 2-Ethylhexyl salicylate has been reported to be found in tea (Camellia sinensis), human (Homo sapiens), and honeysuckle (Lonicera japonica), and relevant data are available.
Drug Indications Sunscreen ingredient used to protect skin from sun damage and prevent sunburn, skin aging, and skin cancer.Mechanism of Action Chemical sunscreens work by absorbing UVB light rather than UVA light. |
| Molecular Formula |
C15H22O3
|
|---|---|
| Molecular Weight |
250.33338
|
| Exact Mass |
250.156
|
| CAS # |
118-60-5
|
| PubChem CID |
8364
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
331.5±15.0 °C at 760 mmHg
|
| Flash Point |
127.7±13.2 °C
|
| Vapour Pressure |
0.0±0.7 mmHg at 25°C
|
| Index of Refraction |
1.510
|
| LogP |
5.77
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
18
|
| Complexity |
240
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C(OCC(CC)CCCC)C1=CC=CC=C1O
|
| InChi Key |
FMRHJJZUHUTGKE-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
|
| Chemical Name |
2-ethylhexyl 2-hydroxybenzoate
|
| Synonyms |
Octyl salicylate; 2-Ethylhexyl salicylate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~399.47 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9947 mL | 19.9736 mL | 39.9473 mL | |
| 5 mM | 0.7989 mL | 3.9947 mL | 7.9895 mL | |
| 10 mM | 0.3995 mL | 1.9974 mL | 3.9947 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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