| Size | Price | Stock | Qty |
|---|---|---|---|
| 10g |
|
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| Other Sizes |
| References | |
|---|---|
| Additional Infomation |
Suberic acid is an α,ω-dicarboxylic acid that is a 1,6-dicarboxylic acid derivative of hexane. It is a human metabolite. It is both an α,ω-dicarboxylic acid and a dicarboxylic acid fatty acid. It is the conjugate acid of octanedioic acid (2-) and octanedioic acid. Suberic acid has been reported in Trichosanthes kirilowii, Stellaria dichotoma, and other organisms with relevant data. See also: Carboxylic acid, di-, C4-11 (note moved here). Suberic acid is a dicarboxylic acid that can be detected in the urine of patients with systemic (medium-chain) acyl-CoA dehydrogenase deficiency (MADD), a disease characterized by nonketotic dicarboxylic aciduria. [1] The literature quantifies the excretion pattern of octanedioic acid in the urine of three MADD patients. Suberic acid is one of 23 biologically significant organic acids. The presence of octanedioic acid in urine is associated with impaired medium-chain fatty acid metabolism, in which a deficiency of medium-chain acyl-CoA dehydrogenase leads to the accumulation and subsequent excretion of dicarboxylic acids, including octanedioic acid. [1] In this context, octanedioic acid is not a therapeutic drug, but a key metabolic marker reflecting metabolic dysfunction in patients with MADD, and the measurement of its urinary excretion level is helpful for the diagnosis and characterization of the disease. [1]
|
| Molecular Formula |
C8H14O4
|
|---|---|
| Molecular Weight |
174.1944
|
| Exact Mass |
174.089
|
| CAS # |
505-48-6
|
| Related CAS # |
Suberic acid-d4;19031-57-3;Suberic acid-d12;169397-99-3
|
| PubChem CID |
10457
|
| Appearance |
White to off-white solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
361.2±25.0 °C at 760 mmHg
|
| Melting Point |
140-144 °C(lit.)
|
| Flash Point |
186.5±19.7 °C
|
| Vapour Pressure |
0.0±1.7 mmHg at 25°C
|
| Index of Refraction |
1.476
|
| LogP |
0.8
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
12
|
| Complexity |
135
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
TYFQFVWCELRYAO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2,(H,9,10)(H,11,12)
|
| Chemical Name |
octanedioic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~574.05 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.25 mg/mL (18.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3.25 mg/mL (18.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 3.25 mg/mL (18.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7409 mL | 28.7043 mL | 57.4086 mL | |
| 5 mM | 1.1482 mL | 5.7409 mL | 11.4817 mL | |
| 10 mM | 0.5741 mL | 2.8704 mL | 5.7409 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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