OATD-01

Alias: OATD-01OATD01OATD 01
Cat No.:V24834 Purity: ≥98%
OATD-01 is a novel, selective andhighly active CHIT1 (chitinase1, hAMCase IC50=9nM, hCHIT1 IC50=26nM) inhibitor with both an excellent PK profile in multiple species and selectivity against a panel of other off-targets.
OATD-01 Chemical Structure CAS No.: 2088453-21-6
Product category: Others 10
This product is for research use only, not for human use. We do not sell to patients.
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Product Description

OATD-01 is a novel, selective and highly active CHIT1 (chitinase1, hAMCase IC50=9nM, hCHIT1 IC50=26nM) inhibitor with both an excellent PK profile in multiple species and selectivity against a panel of other off-targets.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
The inhibitory concentrations (Ki) of the four enzymes are 17.3 nM, 26.05 nM, 4.8 nM, and 5.7 nM, respectively, and OATD-01 has significant affinity for h/mCHIT1 and h/mAMCase [1]. The IC50 values of 23 nM, 28 nM, 9 nM, and 7.8 nM for hCHIT1, mCHIT1, hAMCase, and mAMCase, respectively, are in good correlation with these Ki values [1]. The external evaluation of the off-target effects of Eurofins Panlabs panlabs Compound OATD-01 was conducted in 98 in vitro binding and enzymatic experiments at 10 μM, involving proteins from several molecular classes [1].
ln Vivo
In an animal model of bleomycin-induced lung fibrosis, OATD-01 (oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days) demonstrated a strong anti-fibrotic effectiveness.
Animal Protocol
Animal/Disease Models: Female balb/c (Bagg ALBino) mouse [1]
Doses: 30 mg/kg, 100 mg/kg
Route of Administration: po (oral gavage); the degree of pulmonary fibrosis was finally achieved in this animal model to achieve treatment effects comparable to Nintedanib treatment [1]. 30 mg/kg, 100 mg/kg; one time/day; 21-day
Experimental Results: diminished pulmonary fibrosis in the body[1]
References
[1]. Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C19H27CLN6O
Molecular Weight
390.910282373428
CAS #
2088453-21-6
SMILES
ClC1C=CC(=CC=1)C[C@H]1CO[C@@H](C)CN1C1CCN(C2=NNC(N)=N2)CC1
Synonyms
OATD-01OATD01OATD 01
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~100 mg/mL (~255.81 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.5581 mL 12.7907 mL 25.5813 mL
5 mM 0.5116 mL 2.5581 mL 5.1163 mL
10 mM 0.2558 mL 1.2791 mL 2.5581 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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