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    InvivoChem Cat #: V4538
    CAS #: 902156-99-4Purity ≥98%

    Description: NVP-LCQ195 (formerly also known as AT9311; AT-9311; LCQ195; LCQ-195) is a novel and potent small molecule heterocyclic inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-μmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumour cells in advanced versus early stages of MM. 

    References: Br J Haematol. 2011 Feb;152(4):420-32.

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    NVP-LCQ-195Name: NVP-LCQ195
    CAS#: 902156-99-4
    Chemical Formula: C17H19Cl2N5O4S
    Exact Mass: 459.0535
    Molecular Weight: 460.33
    Elemental Analysis: C, 44.36; H, 4.16; Cl, 15.40; N, 15.21; O, 13.90; S, 6.96
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311; NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195.
    IUPAC/Chemical Name: 4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide
    InChi Code: InChI=1S/C17H19Cl2N5O4S/c1-29(27,28)24-7-5-10(6-8-24)21-17(26)15-13(9-20-23-15)22-16(25)14-11(18)3-2-4-12(14)19/h2-4,9-10H,5-8H2,1H3,(H,20,23)(H,21,26)(H,22,25)
    SMILES Code: O=C(C1=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=NN1)NC3CCN(S(=O)(C)=O)CC3

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    In vitro kinase activity in the presence of LCQ195.  2011 Feb;152(4):420-32.


    LCQ195 cause cell cycle arrest and cell death.  2011 Feb;152(4):420-32.


    Treatment of MM.1S cells with LCQ195 leads to distinct changes in transcriptional signatures of activation of key molecular pathways in tumor cell pathophysiology.  2011 Feb;152(4):420-32.


    Activity of LCQ195 on MM cells.  2011 Feb;152(4):420-32.


    LCQ195 enhances the anti-MM activity of dexamethasone in vitro.  2011 Feb;152(4):420-32. 


    LCQ195 treatment induces a transcriptional response of genes which correlate with clinical outcome.


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