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    Nutlin-3b
    Nutlin-3b

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0043
    CAS #: 675576-97-3 Purity ≥98%

    Description: Nutlin-3b, a less active/inactive isomer of nutlin-3, is a novel antagonist or inhibitor of p53/MDM2 (murine double minute 2) protein protein interaction with IC50 value of 13.6 μM. It is 150-fold less potent than Nutlin-3 in comparison with Nutlin-3a.  

    References:  Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93. Mol Cancer Ther. 2006 Feb;5(2):411-7.

    Related CAS: 890090-75-2; 548472-68-0 (Nutlin-3); 675576-98-4 (Nutlin-3a)

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    Molecular Weight (MW)581.49
    FormulaC30H30Cl2N4O4
    CAS No.675576-97-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (172.0 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol100 mg/mL (172.0 mM)
    SynonymsNutlin3b; Nutlin 3b; Nutlin-3b
    Chemical Name2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-


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    In VitroNutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls.
    In VivoN/A
    Animal modelN/A
    Formulation & DosageN/A
    References[1] Vassilev LT, et al. Science, 2004, 303(5659), 844-848.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Nutlin-3b

     

    Nutlin-3b



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