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    NSC 319726
    NSC 319726

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0017
    CAS #: 71555-25-4Purity ≥98%

    Description: NSC319726 is a novel and potent p53(R175) mutant reactivator with with potential anticancer activity. It exhibits growth inhibition in cells expressing mutant p53 (IC50 of 8 nM for p53(R175) mutant) but shows no inhibition for p53 wild-type cells. 

    References: Cancer Cell. 2012 May 15;21(5):614-25.

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    Molecular Weight (MW)234.32
    FormulaC11H14N4S
    CAS No.71555-25-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 19 mg/mL (81.08 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol:  <1 mg/mL
    SynonymsNSC319726; NSC-319726; NSC 319726


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    GeneralNSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53+/+ and p53-/- mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53+/+) and MDAMB468-p53(R273W) xenografts.
    Animal modelp53+/+, p53-/- and p53R172H knockin mice
    FormulationDMSO
    Dosages5-10 mg/kg/day, up to 7 days
    Administrationi.p.
    References[1] Yu X, et al. Cancer Cell, 2012, 21(5), 614-625.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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