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    NSC 207895
    NSC 207895

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0041
    CAS #: 58131-57-0Purity ≥98%

    Description: NSC 207895 is a novel anticancer agent that is able to suppress MDM2 with an IC50 of 2.5 μM, which leads to enhanced p53 stabilization/activation and DNA damage. It is therefore a p53 activator that also regulates MDM2, an E3 ligase. NSC 207895 is a benzofuroxan derivative and is less toxic. NSC 207895 decreases the activity of MDMX promoter and subsequently decreases both the mRNA and protein levels of MDMX in MCF-7 cells. This inhibition of MDMX is accompanied with the activation of p53. 

    References: Mol Cancer Ther. 2011 Jan;10(1):69-79.


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    Molecular Weight (MW)279.25
    FormulaC11H13N5O4
    CAS No.58131-57-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 0.4 mg/mL (1.43 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL
    Synonyms NSC-207895, NSC207895, XI-006, XI 006, XI006, NSC 207895, NSC179940, NSC-179940, NSC 179940


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    In vitro

    NSC-207895 decreases both the MDMX mRNA and protein in MCF-7 cells. NSC-207895 induces expression of p53 as well as well-characterized p53-target gene, p21 and MDM2, in a dose-dependent manner in MCF-7 cells. NSC-207895 extends the half-life of p53 from 20 to 30 minutes to more than 3 hours as revealed by cycloheximide chase assays in MCF-7 cells.

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    Reference[1] Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    NSC 207895

    NSC-207895 is a DNA damaging agent. Molecular Systems Biology 6(1):451 December 2010 



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