| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
| Targets |
NR2F6 modulator-1 targets nuclear receptor subfamily 2, group F, member 6 (NR2F6). NR2F6 is a nuclear receptor that plays a role in immune system regulation and inflammatory responses. By modulating the activity of this receptor, the compound can influence immune responses and cancer stem cell activity. This makes it a valuable tool for studying immune regulation and cancer biology.
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| ln Vitro |
In vitro, NR2F6 modulator-1 is a potent modulator of NR2F6. It can be used for researching immune modulation and modulation of cancer stem cell activity. Specific in vitro data such as IC50 values are not detailed in the available literature, but the compound is characterized as a potent modulator.
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| ln Vivo |
Specific in vivo data for NR2F6 modulator-1 are limited. Based on its in vitro mechanism, the compound has potential for studying immune regulation and cancer. However, detailed in vivo efficacy studies in animal models have not been extensively reported. The compound is primarily used as a research tool.
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| Enzyme Assay |
In vitro receptor binding assays are used to characterize NR2F6 modulator-1's interaction with NR2F6. Radioligand binding assays or other binding studies can be performed to measure the compound's affinity for the receptor. Functional assays measure the compound's ability to modulate NR2F6-mediated transcriptional activity.
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| Cell Assay |
Cell-based assays for NR2F6 modulator-1 are conducted in immune cells or cancer cell lines. Cells are treated with the compound, and NR2F6 activity is assessed by measuring the expression of NR2F6 target genes. Immune cell function and cancer stem cell activity are also assessed.
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| Animal Protocol |
In vivo animal experiments with NR2F6 modulator-1 have not been extensively documented. Typical study designs would involve administration of the compound in models of immune-mediated diseases or cancer. Dosing regimens and routes of administration would need to be optimized. The compound is for research use only.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of NR2F6 modulator-1 are not extensively characterized. The compound has a molecular formula of C23H17NO5S and a molecular weight of 419.45. Storage: powder at -20°C for 3 years; in solvent at -80°C for 1 year. Specific data on absorption, distribution, metabolism, and excretion are not available.
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| Toxicity/Toxicokinetics |
Safety and toxicology data for NR2F6 modulator-1 are limited. The compound is for research use only and is not approved for human therapeutic use. Standard laboratory safety precautions should be followed when handling the compound. No specific toxicity data are available.
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| References | |
| Additional Infomation |
NR2F6 modulator-1 has CAS number 904449-84-9, molecular formula C23H17NO5S, and molecular weight 419.45. It is a potent modulator of NR2F6. It can be used for researching immune modulation and modulation of cancer stem cell activity. Purity: >97%. Not for human use; for research purposes only.
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| Molecular Formula |
C23H17NO5S
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|---|---|
| Molecular Weight |
419.45
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| Exact Mass |
419.082
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| CAS # |
904449-84-9
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| PubChem CID |
20864493
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
3.7
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
30
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| Complexity |
772
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1(=O)OC2=CC=C(C(NCC3=CC=CC=C3)=O)C=C2C=C1S(C1=CC=CC=C1)(=O)=O
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| InChi Key |
ZNYVQFURPOKGQG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H17NO5S/c25-22(24-15-16-7-3-1-4-8-16)17-11-12-20-18(13-17)14-21(23(26)29-20)30(27,28)19-9-5-2-6-10-19/h1-14H,15H2,(H,24,25)
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| Chemical Name |
3-(benzenesulfonyl)-N-benzyl-2-oxochromene-6-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~298.01 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.96 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3841 mL | 11.9204 mL | 23.8407 mL | |
| 5 mM | 0.4768 mL | 2.3841 mL | 4.7681 mL | |
| 10 mM | 0.2384 mL | 1.1920 mL | 2.3841 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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