| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
The primary target of Novaluron is chitin synthesis in insects. It inhibits the enzyme chitin synthase, which is involved in the production of chitin, a key component of the insect exoskeleton. By inhibiting chitin synthesis, novaluron prevents the formation of the exoskeleton, leading to the death of the insect during molting. The compound is a contact and stomach poison.
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| ln Vitro |
In vitro, novaluron has been shown to inhibit chitin synthesis in insect cell cultures. It reduces the incorporation of labeled precursors into chitin. The compound's insecticidal activity has been confirmed in various in vitro models using insect cell lines.
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| ln Vivo |
In vivo, novaluron is effective in controlling a wide range of insect pests. It is used on crops such as cotton, vegetables, and fruit trees. The compound provides long-lasting control and is effective against both larvae and eggs. It is also used in public health for the control of mosquitoes and other pests.
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| Enzyme Assay |
In vitro enzyme or receptor binding (non-cell) assays for novaluron involve measuring its inhibition of chitin synthase activity. The assay uses a purified chitin synthase enzyme or insect tissue homogenates and a substrate, such as UDP-N-acetylglucosamine. The incorporation of labeled substrate into chitin is measured. The compound is incubated with the enzyme and substrate at varying concentrations, and the IC50 is determined.
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| Cell Assay |
In vitro cell-based assays for novaluron are performed using insect cell lines. Cells are treated with the compound, and chitin synthesis is measured by the incorporation of labeled precursors. The compound's effects on cell viability and insect development are also assessed.
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| Animal Protocol |
In vivo animal experiments for novaluron are conducted using insect models, such as larvae of Lepidoptera or Coleoptera. The compound is applied to the insects or to their food source, and mortality and developmental abnormalities are assessed. These studies confirm the compound's efficacy as an insect growth regulator.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties of novaluron indicate that it is absorbed by insects through contact or ingestion. The compound has a molecular weight of 492.70 and a molecular formula of C17H9ClF8N2O4. It is a solid at room temperature. It is metabolized in insects and has a relatively long residual activity. The compound is typically applied as a spray.
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| Toxicity/Toxicokinetics |
Toxicology (toxicology) data for novaluron indicate that it is of low toxicity to mammals. It is not highly toxic by ingestion or dermal exposure. The compound may cause mild skin and eye irritation. It is toxic to aquatic organisms and should be used with caution near water bodies.
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| References | |
| Additional Infomation |
Novarone is a benzoylurea insecticide belonging to the monochlorobenzene aromatic ether and organofluorine compounds. It is an insecticidal chemical substance, a novel insect growth regulator used to control a variety of pests, including Lepidoptera, Coleoptera, and Diptera. It is a chitin synthesis inhibitor with stomach poison and some contact action. In the United States, this compound has been used on food crops such as apples, potatoes, cruciferous vegetables, ornamental plants, and cotton. The U.S. Environmental Protection Agency and the Pest Management Agency of Canada consider novarone to pose a low risk to the environment and non-target organisms, and regard it as an important option for integrated pest management, helping to reduce dependence on organophosphates, carbamates, and pyrethroids.
Other information: Novaluron is a benzoylurea insecticide used in agriculture and public health. It is also known as Rimon. The compound inhibits chitin synthesis in insects. Its CAS number is 116714-46-6. |
| Molecular Formula |
C17H9CLF8N2O4
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|---|---|
| Molecular Weight |
492.7
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| Exact Mass |
492.012
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| CAS # |
116714-46-6
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| PubChem CID |
93541
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| Appearance |
Off-white to gray solid powder
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| Density |
1.601 g/cm3
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| Melting Point |
177.5ºC
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| Index of Refraction |
1.513
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| LogP |
5.847
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
32
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| Complexity |
661
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(NC(NC1=CC=C(OC(F)(F)C(F)OC(F)(F)F)C(Cl)=C1)=O)C2=C(F)C=CC=C2F
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| InChi Key |
NJPPVKZQTLUDBO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H9ClF8N2O4/c18-8-6-7(4-5-11(8)31-16(22,23)14(21)32-17(24,25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6,14H,(H2,27,28,29,30)
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| Chemical Name |
N-[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]carbamoyl]-2,6-difluorobenzamide
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| Synonyms |
Rimon; Novaluron
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~120 mg/mL (~243.56 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 3 mg/mL (6.09 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (6.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0296 mL | 10.1482 mL | 20.2963 mL | |
| 5 mM | 0.4059 mL | 2.0296 mL | 4.0593 mL | |
| 10 mM | 0.2030 mL | 1.0148 mL | 2.0296 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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