| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
To attach biotin to an amino acid, a reaction with the amino group must occur. One example is biocytin (biotin lysine). However, norbiotinamine can be linked to an amino acid's carboxyl group to form a reverse peptide with the amide bond in the opposite orientation. For instance, norbiotinamine is linked to the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The norbiotinamide of gamma glutamic acid (VII) formed following deprotection resembles biocytin, but it has a shorter aliphatic chain and a reverse amide bond [1].
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|---|---|
| References |
[1]. Szalecki W.Synthesis of Norbiotinamine and its derivatives. Bioconjug Chem. 1996 Mar-Apr;7(2):271-3.
[2]. Zhou GC, et al. Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells.Eur J Med Chem. 2013;70:631-9. |
| Molecular Formula |
C9H17N3OS
|
|---|---|
| Molecular Weight |
215.31578040123
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| Exact Mass |
215.109
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| CAS # |
173401-47-3
|
| PubChem CID |
58635189
|
| Appearance |
Typically exists as solid at room temperature
|
| LogP |
-0.1
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
14
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| Complexity |
224
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| Defined Atom Stereocenter Count |
3
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| SMILES |
C1[C@H]2[C@@H]([C@@H](S1)CCCCN)NC(=O)N2
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| InChi Key |
KRWAZHNVQMITHZ-FXQIFTODSA-N
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| InChi Code |
InChI=1S/C9H17N3OS/c10-4-2-1-3-7-8-6(5-14-7)11-9(13)12-8/h6-8H,1-5,10H2,(H2,11,12,13)/t6-,7-,8-/m0/s1
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| Chemical Name |
(3aS,4S,6aR)-4-(4-aminobutyl)-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~200 mg/mL (~928.85 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (464.43 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6443 mL | 23.2213 mL | 46.4425 mL | |
| 5 mM | 0.9289 mL | 4.6443 mL | 9.2885 mL | |
| 10 mM | 0.4644 mL | 2.3221 mL | 4.6443 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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