| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| 10g |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
In in vitro skin penetration studies using cadaver skin (rinse and residence protocols), nonoxynol-2, -4, and -9 showed total skin penetration of less than 1% over 48 hours. |
|---|---|
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Mouse intraperitoneal injection LD50: 150 mg/kg |
| Additional Infomation |
Tergitol is a polyethylene glycol derivative whose structure involves converting a terminal hydroxyl group of polyethylene glycol into the corresponding p-nonylphenyl ether. It is a nonionic surfactant. It is both a polyethylene glycol derivative and a hydroxyl polyether. The number of repeating ethoxy (oxy-1,2-ethylene glycol) groups in a mixture of nonionic surfactants varies. They can be used as detergents, emulsifiers, wetting agents, defoamers, etc. Nonoxynol-9 is a compound containing nine repeating ethoxy groups; it is a spermicide and is mainly formulated as an ingredient in vaginal foams and creams. See also: Nonoxynol-10 (note moved to); C11-15 secondary alcohols, ethoxylated (note moved to)... See more...
|
| Molecular Formula |
C17H28O2
|
|---|---|
| Molecular Weight |
264.41
|
| Exact Mass |
514.351
|
| CAS # |
26027-38-3
|
| Related CAS # |
26027-38-3
|
| PubChem CID |
7700
|
| Appearance |
Lower adducts (n<15) yellow to almost colorless liquid; higher adducts (n>20) pale yellow to off-white pastes or waxes
|
| Density |
1.06
|
| Boiling Point |
250ºC
|
| Melting Point |
57-58ºC
|
| Flash Point |
94ºC
|
| Index of Refraction |
1.4950-1.4990
|
| LogP |
3.871
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
11
|
| Heavy Atom Count |
19
|
| Complexity |
186
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCCCCCC1=CC=C(OCCO)C=C1.[n]
|
| InChi Key |
KUXGUCNZFCVULO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H28O2/c1-2-3-4-5-6-7-8-9-16-10-12-17(13-11-16)19-15-14-18/h10-13,18H,2-9,14-15H2,1H3
|
| Chemical Name |
2-(4-nonylphenoxy)ethanol
|
| Synonyms |
Delfen; Conceptrol; Nonoxynols
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol : ~50 mg/mL
DMSO : ≥ 45 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7820 mL | 18.9100 mL | 37.8201 mL | |
| 5 mM | 0.7564 mL | 3.7820 mL | 7.5640 mL | |
| 10 mM | 0.3782 mL | 1.8910 mL | 3.7820 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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