| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
|
| ln Vitro |
Treatment with neticonazole (10 μM; 48 h) decreased the levels of Alix and Rab27a and markedly decreased the levels of nSMase2. Significant p-ERK level inhibition is possible with neticonazole [2]. Exosome release from C4-2B cells is potently and dose-dependently inhibited by neticonazole (0–10 μM) [2]. Additionally, neticonazole has an aqueous solution-dependent, biogenic wound-active exosome [3].
|
|---|---|
| ln Vivo |
Neticonazole hydrochloride treatment (1–100 ng/kg; lateral wall tube feeding; once daily; C57BL/6 mice; formulated) increased the contaminating bacterial flora (IDB) cleanup in rats with rectal cancer (CRC) considerably. Tumor xenograft
|
| Cell Assay |
Western Blot Analysis[2]
Cell Types: C4 -2B Cell Tested Concentrations: 10 µM Incubation Duration: 48 hrs (hours) Experimental Results: diminished Alix and Rab27a levels, and Dramatically diminished nSMase2 levels. |
| Animal Protocol |
Animal/Disease Models: Male C57BL/6 mice (8 weeks old) were given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells [3].
Doses: 1 ng/kg, 10 ng/kg, and 100 ng/kg Route of Administration: po (oral gavage); daily; for 15 days Experimental Results: Dramatically improved survival of IDB mice with CRC xenograft tumors. |
| References |
|
| Additional Infomation |
Neticonazole hydrochloride is a hydrochloride resulting from the formal reaction of equimolar amounts of neticonazole and hydrogen chloride. An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan as an antifungal drug for the treatment of superficial skin infections. It has a role as an antifungal drug and an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is a hydrochloride, an imidazole antifungal drug and a conazole antifungal drug. It contains a neticonazole(1+).
|
| Molecular Formula |
C17H22N2OS.HCL
|
|---|---|
| Molecular Weight |
338.8953
|
| Exact Mass |
338.122
|
| CAS # |
130773-02-3
|
| Related CAS # |
Neticonazole;130726-68-0
|
| PubChem CID |
5282432
|
| Appearance |
White to off-white solid powder
|
| Density |
1.06g/cm3
|
| Boiling Point |
464ºC at 760mmHg
|
| Flash Point |
234.4ºC
|
| Vapour Pressure |
8.66E-09mmHg at 25°C
|
| LogP |
5.463
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
22
|
| Complexity |
322
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCOC1=CC=CC=C1/C(=C\SC)/N2C=CN=C2.Cl
|
| InChi Key |
HAHMABKERDVYCH-ZUQRMPMESA-N
|
| InChi Code |
InChI=1S/C17H22N2OS.ClH/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19;/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3;1H/b16-13+;
|
| Chemical Name |
1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~737.68 mM)
H2O : ≥ 100 mg/mL (~295.07 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (18.44 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6.25 mg/mL (18.44 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 6.25 mg/mL (18.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (295.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9507 mL | 14.7536 mL | 29.5072 mL | |
| 5 mM | 0.5901 mL | 2.9507 mL | 5.9014 mL | |
| 10 mM | 0.2951 mL | 1.4754 mL | 2.9507 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
