| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| ln Vitro |
- Myocardial protective activity: Neoglycyrol exhibited protective effects against H₂O₂-induced damage in H9c2 cardiomyocytes. At concentrations of 10 μM, 20 μM, and 40 μM, it increased cell viability by 21%, 38%, and 55% respectively, compared to H₂O₂-treated control cells (viability = 48% of normal control). It also reduced lactate dehydrogenase (LDH) leakage (inhibition rate = 42% at 40 μM) and reactive oxygen species (ROS) production (reduction rate = 51% at 40 μM) [2]
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|---|---|
| Cell Assay |
- Myocardial cell protection assay: H9c2 cardiomyocytes were seeded into 96-well plates at a density of 1×10⁴ cells/well and incubated overnight. Cells were pre-treated with Neoglycyrol (10-40 μM) for 2 hours, then exposed to H₂O₂ (200 μM) for 24 hours to induce oxidative damage. Cell viability was measured using a tetrazolium salt-based colorimetric assay. LDH leakage in the culture supernatant was detected by a colorimetric method, and ROS levels were measured using a ROS-sensitive fluorescent probe with fluorescence intensity detected at excitation 488 nm/emission 525 nm [2]
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| References | |
| Additional Infomation |
Glycyrol belongs to the coumarin class of compounds, with its structure consisting of hydroxyl groups at positions 1 and 9, a methoxy group at position 3, and an isopentenyl group at position 2. It is a plant metabolite and an antitumor drug. Glycyrol is also a polyphenol, δ-lactone, and aromatic ether. Its function is related to coumarin. Glycyrol has been reported to be found in licorice (Glycyrrhiza uralensis), coarse licorice (Glycyrrhiza aspera), and other organisms with relevant data. See also: Licorice (Glycyrrhiza uralensis) root (part). - Natural Source: NeoGlycyrol is a coumarin compound isolated from the root of licorice (Glycyrrhiza uralensis Fisch.). (Fabaceae) [1] - Chemical classification: It belongs to the coumarin class of natural products, characterized by a benzopyranone core structure [1] - Pharmacological potential: Neoglycyrrhizol is considered to be an active ingredient with cardioprotective effects, which may be related to its antioxidant capacity against myocardial cell damage caused by oxidative stress [2]
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| Molecular Formula |
C21H18O6
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|---|---|
| Molecular Weight |
366.3640
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| Exact Mass |
366.11
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| Elemental Analysis |
C, 68.85; H, 4.95; O, 26.20
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| CAS # |
23013-84-5
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| PubChem CID |
5320083
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
493.1±45.0 °C at 760 mmHg
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| Melting Point |
263.5-265℃
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| Flash Point |
252.0±28.7 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.667
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| LogP |
5.45
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
27
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| Complexity |
600
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C2C([H])=C(C([H])=C([H])C=2C2C(=O)OC3C([H])=C(C(C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])=C(C=3C1=2)OC([H])([H])[H])O[H])O[H]
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| InChi Key |
LWESBHWAOZORCQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H18O6/c1-10(2)4-6-12-14(23)9-16-18(19(12)25-3)20-17(21(24)27-16)13-7-5-11(22)8-15(13)26-20/h4-5,7-9,22-23H,6H2,1-3H3
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| Chemical Name |
3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
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| Synonyms |
Neoglycyrol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~16.67 mg/mL (~45.50 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (4.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7296 mL | 13.6478 mL | 27.2956 mL | |
| 5 mM | 0.5459 mL | 2.7296 mL | 5.4591 mL | |
| 10 mM | 0.2730 mL | 1.3648 mL | 2.7296 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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