Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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ln Vitro |
Inhibiting 6-OHDA-induced SH-SY5Y cell activity, increasing oxygen and cell fluorescence, and increasing GSH are all achieved by narcissin (0-1 μM, 24 h)[2]. In Raji cells of α-Narcissin transcription factor Flowchart NL5901 C, narcissin (2 mM, 3 days) decreases TPA-induced activation of Epstein-Barr virus early antigen (EBV-EA). C. elegans [3].
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ln Vivo |
TPA (1.7 nmol) administered topically can cause mouse tumors to grow more slowly than narcissin (85 nmol) [3].
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Cell Assay |
Western Blot Analysis[2]
Cell Types: 6-OHDA-exexped. SH-SY5Y cell Tested Concentrations: 0-1μM Incubation Duration: 24 hrs (hours) Experimental Results: Increased nuclear Nrf2 expression. Inhibits the activation of JNK and p38. |
References |
[1]. Su BN, et al. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.J Nat Prod. 2005 Apr;68(4):592-5.
[2]. Fu RH, et al. Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson's Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway. Antioxidants (Basel). 2022 Oct 23;11(11):2089. [3]. Ito H, et al. Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. Cancer Lett. 1999 Aug 23;143(1):5-13 |
Molecular Formula |
C28H32O16
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Molecular Weight |
624.5441
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Exact Mass |
624.17
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Elemental Analysis |
C, 53.85; H, 5.16; O, 40.99
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CAS # |
604-80-8
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Appearance |
Solid powder
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SMILES |
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)OC)O)O)O)O)O)O
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InChi Key |
UIDGLYUNOUKLBM-GEBJFKNCSA-N
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InChi Code |
InChI=1S/C28H32O16/c1-9-18(32)21(35)23(37)27(41-9)40-8-16-19(33)22(36)24(38)28(43-16)44-26-20(34)17-13(31)6-11(29)7-15(17)42-25(26)10-3-4-12(30)14(5-10)39-2/h3-7,9,16,18-19,21-24,27-33,35-38H,8H2,1-2H3/t9-,16+,18-,19+,21+,22-,23+,24+,27+,28-/m0/s1
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Chemical Name |
5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
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Synonyms |
Narcissoside
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~160.12 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6012 mL | 8.0059 mL | 16.0118 mL | |
5 mM | 0.3202 mL | 1.6012 mL | 3.2024 mL | |
10 mM | 0.1601 mL | 0.8006 mL | 1.6012 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.