| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
|
||
| Other Sizes |
| ADME/Pharmacokinetics |
Metabolism / Metabolites
Acylsarcosine can be absorbed orally or through skin contact, while nitrosamines can enter the body through ingestion, inhalation, or skin contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, thus becoming carcinogens. Sarcosine, on the other hand, is metabolized to glycine by sarcosine dehydrogenase. (A2878, A2879, L1892) |
|---|---|
| Toxicity/Toxicokinetics |
Toxicity Summary
Acylsarcosines themselves are not toxic, but they are nitrosating agents. Nitrosating agents can decompose and/or react, leading to nitrosamine contamination. Nitrosamines, formed from secondary amines and amides in the presence of nitrite ions, are considered carcinogenic. The specific nitrosamine formed from acylsarcosine is N-nitrososarcosine. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are subsequently believed to exert their carcinogenic effects by forming adducts at the N and O atoms of DNA. (L1889, L1890, A2878, A2879, A2880, A2881) |
| References | |
| Additional Infomation |
N-Lauroylsarcosine is an N-acyl amino acid. Lauroylsarcosine is a condensation product of a natural fatty acid and sarcosine, a natural amino acid found in muscles and other body tissues. Acylsarcosines are considered modified fatty acids, with their hydrocarbon chains separated at the α-position by an amide methyl group. They are used as surfactants/cleansers in hair conditioners and cosmetics, and can improve the wetting and penetration of topical medications. Acylsarcosines and their sodium salts are also used in the metal surface treatment and processing industry due to their crystal modification, rust prevention, and corrosion resistance properties. (L1892, A2881) See also: Sodium lauroylsarcosine (note moved to).
|
| Molecular Formula |
C15H29NO3
|
|---|---|
| Molecular Weight |
271.3957
|
| Exact Mass |
271.215
|
| CAS # |
97-78-9
|
| Related CAS # |
68003-46-3 (ammonium salt)
|
| PubChem CID |
7348
|
| Appearance |
White to off-white solid powder
|
| Density |
0.986g/cm3
|
| Boiling Point |
413.2ºC at 760mmHg
|
| Melting Point |
45-49 °C
|
| LogP |
3.45
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
19
|
| Complexity |
254
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BACYUWVYYTXETD-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)
|
| Chemical Name |
2-[dodecanoyl(methyl)amino]acetic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~921.15 mM)
H2O : < 0.1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6846 mL | 18.4230 mL | 36.8460 mL | |
| 5 mM | 0.7369 mL | 3.6846 mL | 7.3692 mL | |
| 10 mM | 0.3685 mL | 1.8423 mL | 3.6846 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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