| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| Targets |
Endogenous Metabolite
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|---|---|
| ln Vitro |
N-Acetyl-L-methionine serves as a stabilized methionine source that bypasses first-pass metabolism, enhancing systemic delivery compared to free methionine. It is FDA-approved as a nutritional supplement (GRAS No. 4679) for enteral/parenteral formulations to correct methionine deficiency.
Mechanistically, it participates in the methionine-cysteine cycle: After deacetylation, liberated methionine is metabolized to S-adenosylmethionine (SAMe) for methylation reactions, while excess homocysteine can be remethylated to methionine or converted to cysteine via transsulfuration, supporting glutathione synthesis [1]
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| ADME/Pharmacokinetics |
N-Acetyl-L-methionine is rapidly deacetylated by intestinal and hepatic acylases to release L-methionine, with peak plasma methionine concentrations occurring within 2h post-oral administration in rats. This metabolic conversion efficiency reaches 85-92% in mammals, making it a bioavailable methionine precursor [1]
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| Toxicity/Toxicokinetics |
Toxicity Summary
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Methionine Safe for use in cosmetics, with qualifications |
| References | |
| Additional Infomation |
N-acetyl-L-methionine is an L-methionine derivative that is L-methionine in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a nutraceutical. It is a N-acetyl-L-amino acid, a L-methionine derivative and a N-acetylmethionine. It is a conjugate acid of a N-acetyl-L-methionine(1-). It is an enantiomer of a N-acetyl-D-methionine.
N-Acetyl-L-methionine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). N-Acetyl-L-methionine has been reported in Drosophila melanogaster, Arabidopsis thaliana, and other organisms with data available. |
| Molecular Formula |
C₇H₁₃NO₃S
|
|---|---|
| Molecular Weight |
191.25
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| Exact Mass |
191.061
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| CAS # |
65-82-7
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| Related CAS # |
N-Acetyl-DL-methionine;1115-47-5;N-Acetyl-L-methionine-d3
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| PubChem CID |
448580
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
371.3±52.0 °C at 760 mmHg
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| Melting Point |
104-107ºC
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| Flash Point |
178.3±30.7 °C
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| Vapour Pressure |
0.0±1.9 mmHg at 25°C
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| Index of Refraction |
1.532
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| LogP |
0.95
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
12
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| Complexity |
172
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
CC(=O)N[C@@H](CCSC)C(=O)O
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| InChi Key |
XUYPXLNMDZIRQH-LURJTMIESA-N
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| InChi Code |
InChI=1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1
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| Chemical Name |
(2S)-2-acetamido-4-methylsulfanylbutanoic acid
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| Synonyms |
NAcetylLmethionine; N-Acetyl-L-methionine; 65-82-7; N-Acetylmethionine; Thiomedon; L-Methionine, N-acetyl-; Methionin; Acetylmethionin; acetyl methionine; N Acetyl L methionine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~522.88 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.07 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.07 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (13.07 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2288 mL | 26.1438 mL | 52.2876 mL | |
| 5 mM | 1.0458 mL | 5.2288 mL | 10.4575 mL | |
| 10 mM | 0.5229 mL | 2.6144 mL | 5.2288 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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