| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
| References | |
|---|---|
| Additional Infomation |
N-acetyl-L-aspartic acid is an N-acyl-L-aspartic acid, where the acyl group is specifically defined as an acetyl group. It possesses nutritional and health-promoting, antioxidant, and metabolic functions in humans, mice, and rats. It is an N-acetyl-L-amino acid and N-acyl-L-aspartic acid. It is the conjugate acid of N-acetyl-L-aspartic acid (2-). N-acetyl-L-aspartic acid is present in or produced by Escherichia coli (K12 strain, MG1655 strain). It has been reported that N-acetyl-L-aspartic acid exists in humans and Caenorhabditis elegans, with relevant data. N-acetyl-aspartic acid is the acetylated form of aspartic acid, synthesized in the mitochondria of neurons from aspartic acid and acetyl-CoA. Although N-acetyl-aspartic acid is highly enriched in neurons, its exact biological function remains unclear. N-acetyl-aspartic acid can serve as a neuronal marker; its levels are reduced in the brain under many neuropathological conditions. N-acetylaspartate is a derivative of aspartate. It is the second most concentrated molecule in the brain, after the amino acid glutamate. It is synthesized from the amino acid aspartate and acetyl-CoA in neurons. The various functions of N-acetylaspartate are still under investigation, but its main functions include: 1) acting as a neuronal osmotic regulator, participating in the brain's fluid homeostasis; 2) serving as a source of acetate required for lipid and myelin synthesis in oligodendrocytes (glial cells that form the axons of myelinated neurons); 3) serving as a precursor for the synthesis of the important neuronal dipeptide N-acetylaspartylglutamate; and 4) N-acetylaspartate may also participate in the process of energy production from the amino acid glutamate in neuronal mitochondria.
|
| Molecular Formula |
C6H9NO5
|
|---|---|
| Molecular Weight |
175.1394
|
| Exact Mass |
175.048
|
| CAS # |
997-55-7
|
| PubChem CID |
65065
|
| Appearance |
White to off-white solid powder
|
| Density |
1.5±0.1 g/cm3
|
| Boiling Point |
329.1±52.0 °C at 760 mmHg
|
| Melting Point |
137-140 °C(lit.)
|
| Flash Point |
152.8±30.7 °C
|
| Vapour Pressure |
0.0±1.6 mmHg at 25°C
|
| Index of Refraction |
1.538
|
| LogP |
-0.09
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
12
|
| Complexity |
212
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
CC(=O)N[C@@H](CC(=O)O)C(=O)O
|
| InChi Key |
OTCCIMWXFLJLIA-BYPYZUCNSA-N
|
| InChi Code |
InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
|
| Chemical Name |
(2S)-2-acetamidobutanedioic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~62.5 mg/mL (~356.86 mM)
DMSO : ~5 mg/mL (~28.55 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 12.5 mg/mL (71.37 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7097 mL | 28.5486 mL | 57.0972 mL | |
| 5 mM | 1.1419 mL | 5.7097 mL | 11.4194 mL | |
| 10 mM | 0.5710 mL | 2.8549 mL | 5.7097 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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