| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Myristalkonium chloride targets the cell membranes of bacteria and other microorganisms. As a cationic surfactant, it disrupts the lipid bilayer of the cell membrane, leading to leakage of cellular contents and cell death. It is effective against a broad spectrum of bacteria, fungi, and some viruses. Its mechanism of action is non-specific and physical.
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|---|---|
| ln Vitro |
Benzyldimethyltetradecyl ammonium chloride is a biochemical reagent that can be utilized in life science research as an organic compound or biological material.
In vitro, myristalkonium chloride shows potent antimicrobial activity against a wide range of microorganisms. Its efficacy is measured by determining the minimum inhibitory concentration (MIC) against various bacterial and fungal strains. It is also used as a preservative to prevent microbial growth in formulations. |
| ln Vivo |
In vivo, myristalkonium chloride is used as a topical antiseptic and disinfectant. It is found in various over-the-counter products, such as first-aid antiseptics and hand sanitizers. It is not used systemically due to its toxicity.
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| Enzyme Assay |
In vitro antimicrobial susceptibility testing for myristalkonium chloride is performed using standard methods, such as broth microdilution or agar dilution, to determine the MIC against test organisms. The compound is dissolved in an appropriate solvent and serially diluted in growth medium. Inoculated plates are incubated, and the MIC is determined as the lowest concentration that inhibits visible growth.
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| Cell Assay |
Cell-based studies are not typical for myristalkonium chloride, as it is a biocide rather than a therapeutic agent targeting a specific cellular pathway. Its effects are assessed in antimicrobial susceptibility tests.
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| Animal Protocol |
In vivo, myristalkonium chloride is used in topical formulations. It is applied to the skin for its antiseptic properties. It is not administered systemically.
|
| ADME/Pharmacokinetics |
Myristalkonium chloride is used topically and is poorly absorbed through the skin. It is a quaternary ammonium compound.
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| Toxicity/Toxicokinetics |
Toxicity Summary
Identification and Uses: Tetradecyl dimethyl benzyl ammonium chloride is a white crystalline powder. It is used as a surfactant and detergent. It is a US-registered insecticide and can be used as an algaecide, bactericide, bacteriostatic agent, wood preservative, fungicide, bacteriostatic agent, viricide, tuberculosis bactericide, insecticide, bactericide, bacteriostatic agent, molluscicide, deodorant, disinfectant, and cleaning agent. Human Exposure and Toxicity: No human data found. Animal Studies: Tetradecyl dimethyl benzyl ammonium chloride was corrosive in rabbit skin tests but did not show sensitization in guinea pigs. Based on studies in rats and mice, it is not carcinogenic. It is not mutagenic or genotoxic. It has strong hemolytic activity against rabbit erythrocytes. Non-human toxicity values Dermal LD50 in rats: 704 mg/kg (female) /ADBAC/ Dermal LD50 in rats: 1100 mg/kg (male) /ADBAC/ Dermal LD50 in rats: 930 mg/kg /ADBAC/ Oral LD50 in rats: 280.8 mg/kg (female) /ADBAC/ For more complete non-human toxicity data for tetradecylbenzyldimethylammonium chloride (6 types in total), please visit the HSDB record page. Myristalkonium chloride can be irritating to the skin and eyes. It is toxic if ingested. It should be handled with appropriate safety precautions. |
| Additional Infomation |
See also: ...View more...
Myristalkonium chloride is a quaternary ammonium compound used as a disinfectant, antiseptic, and preservative. Its primary applications are in the pharmaceutical, personal care, and industrial cleaning sectors. It is not a drug used for systemic therapy. It is commercially available from various chemical suppliers. |
| Molecular Formula |
C23H42N+.CL-
|
|---|---|
| Molecular Weight |
368.03928
|
| Exact Mass |
367.3
|
| CAS # |
139-08-2
|
| Related CAS # |
16287-71-1 (Parent)
|
| PubChem CID |
8755
|
| Appearance |
Free-flowing powder
White crystalline powder |
| Melting Point |
60-61 °C
|
| LogP |
3.968
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
25
|
| Complexity |
265
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1
|
| InChi Key |
OCBHHZMJRVXXQK-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C23H42N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-18-21-24(2,3)22-23-19-16-15-17-20-23;/h15-17,19-20H,4-14,18,21-22H2,1-3H3;1H/q+1;/p-1
|
| Chemical Name |
benzyl-dimethyl-tetradecylazanium;chloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~271.7 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.79 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.79 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (6.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7171 mL | 13.5855 mL | 27.1710 mL | |
| 5 mM | 0.5434 mL | 2.7171 mL | 5.4342 mL | |
| 10 mM | 0.2717 mL | 1.3585 mL | 2.7171 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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